The Role of Metformin in Controlling Oxidative Stress in Muscle of Diabetic Rats
المؤلفون المشاركون
Espindola, Foued Salmen
Diniz Vilela, Danielle
Gomes Peixoto, Leonardo
Teixeira, Renata Roland
Belele Baptista, Nathalia
Carvalho Caixeta, Douglas
Vieira de Souza, Adriele
Machado, Hélen Lara
Pereira, Mariana Nunes
Sabino-Silva, Robinson
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Metformin can act in muscle, inhibiting the complex I of the electron transport chain and decreasing mitochondrial reactive oxygen species.
Our hypothesis is that the inhibition of complex I can minimize damage oxidative in muscles of hypoinsulinemic rats.
The present study investigated the effects of insulin and/or metformin treatment on oxidative stress levels in the gastrocnemius muscle of diabetic rats.
Rats were rendered diabetic (D) with an injection of streptozotocin and were submitted to treatment with insulin (D+I), metformin (D+M), or insulin plus metformin (D+I+M) for 7 days.
The body weight, glycemic control, and insulin resistance were evaluated.
Then, oxidative stress levels, glutathione antioxidant defense system, and antioxidant status were analyzed in the gastrocnemius muscle of hypoinsulinemic rats.
The body weight decreased in D+M compared to ND rats.
D+I and D+I+M rats decreased the glycemia and D+I+M rats increased the insulin sensitivity compared to D rats.
D+I+M reduced the oxidative stress levels and the activity of catalase and superoxide dismutase in skeletal muscle when compared to D+I rats.
In conclusion, our results reveal that dual therapy with metformin and insulin promotes more benefits to oxidative stress control in muscle of hypoinsulinemic rats than insulinotherapy alone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Diniz Vilela, Danielle& Gomes Peixoto, Leonardo& Teixeira, Renata Roland& Belele Baptista, Nathalia& Carvalho Caixeta, Douglas& Vieira de Souza, Adriele…[et al.]. 2016. The Role of Metformin in Controlling Oxidative Stress in Muscle of Diabetic Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114159
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Diniz Vilela, Danielle…[et al.]. The Role of Metformin in Controlling Oxidative Stress in Muscle of Diabetic Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114159
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Diniz Vilela, Danielle& Gomes Peixoto, Leonardo& Teixeira, Renata Roland& Belele Baptista, Nathalia& Carvalho Caixeta, Douglas& Vieira de Souza, Adriele…[et al.]. The Role of Metformin in Controlling Oxidative Stress in Muscle of Diabetic Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114159
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114159
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر