The Role of Metformin in Controlling Oxidative Stress in Muscle of Diabetic Rats
Joint Authors
Espindola, Foued Salmen
Diniz Vilela, Danielle
Gomes Peixoto, Leonardo
Teixeira, Renata Roland
Belele Baptista, Nathalia
Carvalho Caixeta, Douglas
Vieira de Souza, Adriele
Machado, Hélen Lara
Pereira, Mariana Nunes
Sabino-Silva, Robinson
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Metformin can act in muscle, inhibiting the complex I of the electron transport chain and decreasing mitochondrial reactive oxygen species.
Our hypothesis is that the inhibition of complex I can minimize damage oxidative in muscles of hypoinsulinemic rats.
The present study investigated the effects of insulin and/or metformin treatment on oxidative stress levels in the gastrocnemius muscle of diabetic rats.
Rats were rendered diabetic (D) with an injection of streptozotocin and were submitted to treatment with insulin (D+I), metformin (D+M), or insulin plus metformin (D+I+M) for 7 days.
The body weight, glycemic control, and insulin resistance were evaluated.
Then, oxidative stress levels, glutathione antioxidant defense system, and antioxidant status were analyzed in the gastrocnemius muscle of hypoinsulinemic rats.
The body weight decreased in D+M compared to ND rats.
D+I and D+I+M rats decreased the glycemia and D+I+M rats increased the insulin sensitivity compared to D rats.
D+I+M reduced the oxidative stress levels and the activity of catalase and superoxide dismutase in skeletal muscle when compared to D+I rats.
In conclusion, our results reveal that dual therapy with metformin and insulin promotes more benefits to oxidative stress control in muscle of hypoinsulinemic rats than insulinotherapy alone.
American Psychological Association (APA)
Diniz Vilela, Danielle& Gomes Peixoto, Leonardo& Teixeira, Renata Roland& Belele Baptista, Nathalia& Carvalho Caixeta, Douglas& Vieira de Souza, Adriele…[et al.]. 2016. The Role of Metformin in Controlling Oxidative Stress in Muscle of Diabetic Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114159
Modern Language Association (MLA)
Diniz Vilela, Danielle…[et al.]. The Role of Metformin in Controlling Oxidative Stress in Muscle of Diabetic Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114159
American Medical Association (AMA)
Diniz Vilela, Danielle& Gomes Peixoto, Leonardo& Teixeira, Renata Roland& Belele Baptista, Nathalia& Carvalho Caixeta, Douglas& Vieira de Souza, Adriele…[et al.]. The Role of Metformin in Controlling Oxidative Stress in Muscle of Diabetic Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114159