Binge Drinking of Ethanol during Adolescence Induces Oxidative Damage and Morphological Changes in Salivary Glands of Female Rats
المؤلفون المشاركون
Maia, Cristiane Socorro Ferraz
Fernandes, Luanna Melo Pereira
Lima, Rafael Rodrigues
Crespo-López, Maria Elena
Fagundes, Nathalia Carolina Fernandes
Paraense, Ricardo Sousa de Oliveira
de Farias-Junior, Paulo Mecenas Alves
Teixeira, Francisco Bruno
Alves-Junior, Sergio Melo
Pinheiro, João de Jesus Viana
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This study investigates morphological and biochemistry effects of binge ethanol consumption in parotid (PG) and submandibular (SG) salivary glands of rats from adolescence to adulthood.
Female Wistar rats ( n = 26 ) received ethanol at 3 g/kg/day (20% w/v) for 3 consecutive days/week from the 35th until the 62nd day of life.
Animals were treated in two periods: 1 week (G1) and 4 weeks (G2), with a control (treated with distilled water) and an ethanol group to each period.
In morphological analysis, morphometric and immunohistochemistry evaluation for smooth muscle actin (αSMA), cytokeratin-18 (CK-18), and vimentin (VIM) were made.
Biochemical changes were analyzed by concentration of nitrites and levels of malondialdehyde (MDA).
The difference between groups in each analysis was evaluated by Mann-Whitney U test or Student’s t -test ( p ≤ 0.05 ).
PG showed, at one week of ethanol exposure, lower CK-18 and α-SMA expression, as well as MDA levels.
After four weeks, lower CK-18 and higher MDA levels were observed in PG exposed to ethanol, in comparison to control group.
SG showed lower α-SMA expression after 1 and 4 weeks of ethanol exposure as well as higher MDA levels after 1 week.
Ethanol binge consumption during adolescence promotes tissue and biochemical changes with only one-week binge in acinar and myoepithelial PG cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fagundes, Nathalia Carolina Fernandes& Fernandes, Luanna Melo Pereira& Paraense, Ricardo Sousa de Oliveira& de Farias-Junior, Paulo Mecenas Alves& Teixeira, Francisco Bruno& Alves-Junior, Sergio Melo…[et al.]. 2016. Binge Drinking of Ethanol during Adolescence Induces Oxidative Damage and Morphological Changes in Salivary Glands of Female Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114184
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fagundes, Nathalia Carolina Fernandes…[et al.]. Binge Drinking of Ethanol during Adolescence Induces Oxidative Damage and Morphological Changes in Salivary Glands of Female Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114184
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fagundes, Nathalia Carolina Fernandes& Fernandes, Luanna Melo Pereira& Paraense, Ricardo Sousa de Oliveira& de Farias-Junior, Paulo Mecenas Alves& Teixeira, Francisco Bruno& Alves-Junior, Sergio Melo…[et al.]. Binge Drinking of Ethanol during Adolescence Induces Oxidative Damage and Morphological Changes in Salivary Glands of Female Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114184
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114184
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر