Binge Drinking of Ethanol during Adolescence Induces Oxidative Damage and Morphological Changes in Salivary Glands of Female Rats
Joint Authors
Maia, Cristiane Socorro Ferraz
Fernandes, Luanna Melo Pereira
Lima, Rafael Rodrigues
Crespo-López, Maria Elena
Fagundes, Nathalia Carolina Fernandes
Paraense, Ricardo Sousa de Oliveira
de Farias-Junior, Paulo Mecenas Alves
Teixeira, Francisco Bruno
Alves-Junior, Sergio Melo
Pinheiro, João de Jesus Viana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study investigates morphological and biochemistry effects of binge ethanol consumption in parotid (PG) and submandibular (SG) salivary glands of rats from adolescence to adulthood.
Female Wistar rats ( n = 26 ) received ethanol at 3 g/kg/day (20% w/v) for 3 consecutive days/week from the 35th until the 62nd day of life.
Animals were treated in two periods: 1 week (G1) and 4 weeks (G2), with a control (treated with distilled water) and an ethanol group to each period.
In morphological analysis, morphometric and immunohistochemistry evaluation for smooth muscle actin (αSMA), cytokeratin-18 (CK-18), and vimentin (VIM) were made.
Biochemical changes were analyzed by concentration of nitrites and levels of malondialdehyde (MDA).
The difference between groups in each analysis was evaluated by Mann-Whitney U test or Student’s t -test ( p ≤ 0.05 ).
PG showed, at one week of ethanol exposure, lower CK-18 and α-SMA expression, as well as MDA levels.
After four weeks, lower CK-18 and higher MDA levels were observed in PG exposed to ethanol, in comparison to control group.
SG showed lower α-SMA expression after 1 and 4 weeks of ethanol exposure as well as higher MDA levels after 1 week.
Ethanol binge consumption during adolescence promotes tissue and biochemical changes with only one-week binge in acinar and myoepithelial PG cells.
American Psychological Association (APA)
Fagundes, Nathalia Carolina Fernandes& Fernandes, Luanna Melo Pereira& Paraense, Ricardo Sousa de Oliveira& de Farias-Junior, Paulo Mecenas Alves& Teixeira, Francisco Bruno& Alves-Junior, Sergio Melo…[et al.]. 2016. Binge Drinking of Ethanol during Adolescence Induces Oxidative Damage and Morphological Changes in Salivary Glands of Female Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114184
Modern Language Association (MLA)
Fagundes, Nathalia Carolina Fernandes…[et al.]. Binge Drinking of Ethanol during Adolescence Induces Oxidative Damage and Morphological Changes in Salivary Glands of Female Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114184
American Medical Association (AMA)
Fagundes, Nathalia Carolina Fernandes& Fernandes, Luanna Melo Pereira& Paraense, Ricardo Sousa de Oliveira& de Farias-Junior, Paulo Mecenas Alves& Teixeira, Francisco Bruno& Alves-Junior, Sergio Melo…[et al.]. Binge Drinking of Ethanol during Adolescence Induces Oxidative Damage and Morphological Changes in Salivary Glands of Female Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114184