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Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients
المؤلفون المشاركون
Vargas-Alarcón, Gilberto
García-Niño, Wylly Ramsés
Jiménez-Osorio, Angélica Saraí
Moreno-Macías, Hortensia
Rodríguez-Arellano, Martha Eunice
Barquera, Rodrigo
Pedraza-Chaverri, José
González-Reyes, Susana
Zuñiga, Joaquin
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The nuclear factor-erythroid 2- (NF-E2-) related factor 2 (Nrf2) is abated and its ability to reduce oxidative stress is impaired in type 2 diabetes and obesity.
Thus, the aim of this study was to explore if polymorphisms in Nrf2 and target genes are associated with diabetes and obesity in Mexican mestizo subjects.
The rs1800566 of NAD(P)H:quinone oxidoreductase 1 (NQO1) gene, rs7211 of thioredoxin interacting protein (TXNIP) gene, rs2071749 of heme oxygenase-1 (HMOX1) gene, and the rs6721961 and the rs2364723 from Nrf2 gene were genotyped in 627 diabetic subjects and 1020 controls.
The results showed that the rs7211 polymorphism is a protective factor against obesity in nondiabetic subjects (CC + CT versus TT, OR = 0.40, P = 0.005 ) and in women (CC versus CT + TT, OR = 0.7, P = 0.016 ).
TT carriers had lower high-density lipoprotein cholesterol levels and lower body mass index.
The rs2071749 was positively associated with obesity (AA versus AG + GG, OR = 1.25, P = 0.026 ).
Finally, the rs6721961 was negatively associated with diabetes in men (CC versus CA + AA, OR = 0.62, P = 0.003 ).
AA carriers showed lower glucose concentrations.
No association was found for rs1800566 and rs2364723 polymorphisms.
In conclusion, the presence of Nrf2 and related genes polymorphisms are associated with diabetes and obesity in Mexican patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiménez-Osorio, Angélica Saraí& González-Reyes, Susana& García-Niño, Wylly Ramsés& Moreno-Macías, Hortensia& Rodríguez-Arellano, Martha Eunice& Vargas-Alarcón, Gilberto…[et al.]. 2016. Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114188
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiménez-Osorio, Angélica Saraí…[et al.]. Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114188
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiménez-Osorio, Angélica Saraí& González-Reyes, Susana& García-Niño, Wylly Ramsés& Moreno-Macías, Hortensia& Rodríguez-Arellano, Martha Eunice& Vargas-Alarcón, Gilberto…[et al.]. Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114188
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114188
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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