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Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients
Joint Authors
Vargas-Alarcón, Gilberto
García-Niño, Wylly Ramsés
Jiménez-Osorio, Angélica Saraí
Moreno-Macías, Hortensia
Rodríguez-Arellano, Martha Eunice
Barquera, Rodrigo
Pedraza-Chaverri, José
González-Reyes, Susana
Zuñiga, Joaquin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The nuclear factor-erythroid 2- (NF-E2-) related factor 2 (Nrf2) is abated and its ability to reduce oxidative stress is impaired in type 2 diabetes and obesity.
Thus, the aim of this study was to explore if polymorphisms in Nrf2 and target genes are associated with diabetes and obesity in Mexican mestizo subjects.
The rs1800566 of NAD(P)H:quinone oxidoreductase 1 (NQO1) gene, rs7211 of thioredoxin interacting protein (TXNIP) gene, rs2071749 of heme oxygenase-1 (HMOX1) gene, and the rs6721961 and the rs2364723 from Nrf2 gene were genotyped in 627 diabetic subjects and 1020 controls.
The results showed that the rs7211 polymorphism is a protective factor against obesity in nondiabetic subjects (CC + CT versus TT, OR = 0.40, P = 0.005 ) and in women (CC versus CT + TT, OR = 0.7, P = 0.016 ).
TT carriers had lower high-density lipoprotein cholesterol levels and lower body mass index.
The rs2071749 was positively associated with obesity (AA versus AG + GG, OR = 1.25, P = 0.026 ).
Finally, the rs6721961 was negatively associated with diabetes in men (CC versus CA + AA, OR = 0.62, P = 0.003 ).
AA carriers showed lower glucose concentrations.
No association was found for rs1800566 and rs2364723 polymorphisms.
In conclusion, the presence of Nrf2 and related genes polymorphisms are associated with diabetes and obesity in Mexican patients.
American Psychological Association (APA)
Jiménez-Osorio, Angélica Saraí& González-Reyes, Susana& García-Niño, Wylly Ramsés& Moreno-Macías, Hortensia& Rodríguez-Arellano, Martha Eunice& Vargas-Alarcón, Gilberto…[et al.]. 2016. Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114188
Modern Language Association (MLA)
Jiménez-Osorio, Angélica Saraí…[et al.]. Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114188
American Medical Association (AMA)
Jiménez-Osorio, Angélica Saraí& González-Reyes, Susana& García-Niño, Wylly Ramsés& Moreno-Macías, Hortensia& Rodríguez-Arellano, Martha Eunice& Vargas-Alarcón, Gilberto…[et al.]. Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114188