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Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases
المؤلف
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that binds to antioxidant response elements located in the promoter region of genes encoding many antioxidant enzymes and phase II detoxifying enzymes.
Activation of Nrf2 functions is one of the critical defensive mechanisms against oxidative stress in many species.
The retina is constantly exposed to reactive oxygen species, and oxidative stress is a major contributor to age-related macular diseases.
Moreover, the resulting inflammation and neuronal degeneration are also related to other retinal diseases.
The well-known Nrf2 activators, bardoxolone methyl and its derivatives, have been the subject of a number of clinical trials, including those aimed at treating chronic kidney disease, pulmonary arterial hypertension, and mitochondrial myopathies.
Recent studies suggest that Nrf2 activation protects the retina from retinal diseases.
In particular, this is supported by the finding that Nrf2 knockout mice display age-related retinal degeneration.
Moreover, the concept has been validated by the efficacy of Nrf2 activators in a number of retinal pathological models.
We have also recently succeeded in generating a novel Nrf2 activator, RS9, using a biotransformation technique.
This review discusses current links between retinal diseases and Nrf2 and the possibility of treating retinal diseases by activating the Nrf2 signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nakagami, Yasuhiro. 2016. Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114199
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nakagami, Yasuhiro. Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114199
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nakagami, Yasuhiro. Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114199
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114199
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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