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Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that binds to antioxidant response elements located in the promoter region of genes encoding many antioxidant enzymes and phase II detoxifying enzymes.
Activation of Nrf2 functions is one of the critical defensive mechanisms against oxidative stress in many species.
The retina is constantly exposed to reactive oxygen species, and oxidative stress is a major contributor to age-related macular diseases.
Moreover, the resulting inflammation and neuronal degeneration are also related to other retinal diseases.
The well-known Nrf2 activators, bardoxolone methyl and its derivatives, have been the subject of a number of clinical trials, including those aimed at treating chronic kidney disease, pulmonary arterial hypertension, and mitochondrial myopathies.
Recent studies suggest that Nrf2 activation protects the retina from retinal diseases.
In particular, this is supported by the finding that Nrf2 knockout mice display age-related retinal degeneration.
Moreover, the concept has been validated by the efficacy of Nrf2 activators in a number of retinal pathological models.
We have also recently succeeded in generating a novel Nrf2 activator, RS9, using a biotransformation technique.
This review discusses current links between retinal diseases and Nrf2 and the possibility of treating retinal diseases by activating the Nrf2 signaling pathway.
American Psychological Association (APA)
Nakagami, Yasuhiro. 2016. Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114199
Modern Language Association (MLA)
Nakagami, Yasuhiro. Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114199
American Medical Association (AMA)
Nakagami, Yasuhiro. Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114199