MnTBAP Therapy Attenuates Renal Fibrosis in Mice with 56 Nephrectomy
المؤلفون المشاركون
Gong, Wei
Zhang, Yue
Yu, Jing
Mao, Song
Huang, Songming
Zhang, Aihua
Jia, Zhanjun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Renal fibrosis is a common pathological feature of all kinds of chronic kidney diseases (CKDs) with uncertain mechanisms.
Accumulating evidence demonstrated an important role of oxidative stress in the pathogenesis of CKD.
Here we hypothesized that MnTBAP (manganese (III) tetrakis (4-benzoic acid)porphyrin chloride), a cell-permeable mimic of superoxide dismutase (SOD), may protect against the fibrotic response in CKD by antagonizing oxidative stress.
To verify this hypothesis, we performed experiments in tubular epithelial cells and mice with 5/6 nephrectomy (Nx).
In mouse tubular epithelial cells, TGF-β1 induced a significant transition to fibrotic phenotype in line with a remarkable mitochondrial dysfunction, which was markedly improved by MnTBAP (1.14 μM) pretreatment.
In remnant kidneys of 5/6 Nx mice, tubulointerstitial fibrosis occurred in parallel with mitochondrial abnormality in renal tubular cells.
Administration of MnTBAP significantly attenuated the deposition of extracellular matrix as evidenced by the blocked expressions of fibronectin, collagen I, and collagen III.
Masson staining also displayed an ameliorated accumulation of collagenous matrix in MnTBAP-treated mice.
Moreover, MnTBAP also significantly improved the severity of proteinuria without altering CKD-related hypertension.
Collectively, MnTBAP therapy served as a promising strategy in preventing renal fibrosis in CKDs possibly via antagonizing mitochondrial-derived oxidative stress and subsequent protection of mitochondrial function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Jing& Mao, Song& Zhang, Yue& Gong, Wei& Jia, Zhanjun& Huang, Songming…[et al.]. 2016. MnTBAP Therapy Attenuates Renal Fibrosis in Mice with 56 Nephrectomy. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114201
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Jing…[et al.]. MnTBAP Therapy Attenuates Renal Fibrosis in Mice with 56 Nephrectomy. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114201
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Jing& Mao, Song& Zhang, Yue& Gong, Wei& Jia, Zhanjun& Huang, Songming…[et al.]. MnTBAP Therapy Attenuates Renal Fibrosis in Mice with 56 Nephrectomy. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114201
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114201
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر