MnTBAP Therapy Attenuates Renal Fibrosis in Mice with 56 Nephrectomy
Joint Authors
Gong, Wei
Zhang, Yue
Yu, Jing
Mao, Song
Huang, Songming
Zhang, Aihua
Jia, Zhanjun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Renal fibrosis is a common pathological feature of all kinds of chronic kidney diseases (CKDs) with uncertain mechanisms.
Accumulating evidence demonstrated an important role of oxidative stress in the pathogenesis of CKD.
Here we hypothesized that MnTBAP (manganese (III) tetrakis (4-benzoic acid)porphyrin chloride), a cell-permeable mimic of superoxide dismutase (SOD), may protect against the fibrotic response in CKD by antagonizing oxidative stress.
To verify this hypothesis, we performed experiments in tubular epithelial cells and mice with 5/6 nephrectomy (Nx).
In mouse tubular epithelial cells, TGF-β1 induced a significant transition to fibrotic phenotype in line with a remarkable mitochondrial dysfunction, which was markedly improved by MnTBAP (1.14 μM) pretreatment.
In remnant kidneys of 5/6 Nx mice, tubulointerstitial fibrosis occurred in parallel with mitochondrial abnormality in renal tubular cells.
Administration of MnTBAP significantly attenuated the deposition of extracellular matrix as evidenced by the blocked expressions of fibronectin, collagen I, and collagen III.
Masson staining also displayed an ameliorated accumulation of collagenous matrix in MnTBAP-treated mice.
Moreover, MnTBAP also significantly improved the severity of proteinuria without altering CKD-related hypertension.
Collectively, MnTBAP therapy served as a promising strategy in preventing renal fibrosis in CKDs possibly via antagonizing mitochondrial-derived oxidative stress and subsequent protection of mitochondrial function.
American Psychological Association (APA)
Yu, Jing& Mao, Song& Zhang, Yue& Gong, Wei& Jia, Zhanjun& Huang, Songming…[et al.]. 2016. MnTBAP Therapy Attenuates Renal Fibrosis in Mice with 56 Nephrectomy. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114201
Modern Language Association (MLA)
Yu, Jing…[et al.]. MnTBAP Therapy Attenuates Renal Fibrosis in Mice with 56 Nephrectomy. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114201
American Medical Association (AMA)
Yu, Jing& Mao, Song& Zhang, Yue& Gong, Wei& Jia, Zhanjun& Huang, Songming…[et al.]. MnTBAP Therapy Attenuates Renal Fibrosis in Mice with 56 Nephrectomy. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114201