Nutrients, Microglia Aging, and Brain Aging
المؤلفون المشاركون
Yu, Janchun
Zhu, Aiqin
Nakanishi, Hiroshi
Wu, Zhou
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
As the life expectancy continues to increase, the cognitive decline associated with Alzheimer’s disease (AD) becomes a big major issue in the world.
After cellular activation upon systemic inflammation, microglia, the resident immune cells in the brain, start to release proinflammatory mediators to trigger neuroinflammation.
We have found that chronic systemic inflammatory challenges induce differential age-dependent microglial responses, which are in line with the impairment of learning and memory, even in middle-aged animals.
We thus raise the concept of “microglia aging.” This concept is based on the fact that microglia are the key contributor to the acceleration of cognitive decline, which is the major sign of brain aging.
On the other hand, inflammation induces oxidative stress and DNA damage, which leads to the overproduction of reactive oxygen species by the numerous types of cells, including macrophages and microglia.
Oxidative stress-damaged cells successively produce larger amounts of inflammatory mediators to promote microglia aging.
Nutrients are necessary for maintaining general health, including the health of brain.
The intake of antioxidant nutrients reduces both systemic inflammation and neuroinflammation and thus reduces cognitive decline during aging.
We herein review our microglia aging concept and discuss systemic inflammation and microglia aging.
We propose that a nutritional approach to controlling microglia aging will open a new window for healthy brain aging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Zhou& Yu, Janchun& Zhu, Aiqin& Nakanishi, Hiroshi. 2016. Nutrients, Microglia Aging, and Brain Aging. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114202
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Zhou…[et al.]. Nutrients, Microglia Aging, and Brain Aging. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114202
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Zhou& Yu, Janchun& Zhu, Aiqin& Nakanishi, Hiroshi. Nutrients, Microglia Aging, and Brain Aging. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114202
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114202
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر