Nutrients, Microglia Aging, and Brain Aging
Joint Authors
Yu, Janchun
Zhu, Aiqin
Nakanishi, Hiroshi
Wu, Zhou
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
As the life expectancy continues to increase, the cognitive decline associated with Alzheimer’s disease (AD) becomes a big major issue in the world.
After cellular activation upon systemic inflammation, microglia, the resident immune cells in the brain, start to release proinflammatory mediators to trigger neuroinflammation.
We have found that chronic systemic inflammatory challenges induce differential age-dependent microglial responses, which are in line with the impairment of learning and memory, even in middle-aged animals.
We thus raise the concept of “microglia aging.” This concept is based on the fact that microglia are the key contributor to the acceleration of cognitive decline, which is the major sign of brain aging.
On the other hand, inflammation induces oxidative stress and DNA damage, which leads to the overproduction of reactive oxygen species by the numerous types of cells, including macrophages and microglia.
Oxidative stress-damaged cells successively produce larger amounts of inflammatory mediators to promote microglia aging.
Nutrients are necessary for maintaining general health, including the health of brain.
The intake of antioxidant nutrients reduces both systemic inflammation and neuroinflammation and thus reduces cognitive decline during aging.
We herein review our microglia aging concept and discuss systemic inflammation and microglia aging.
We propose that a nutritional approach to controlling microglia aging will open a new window for healthy brain aging.
American Psychological Association (APA)
Wu, Zhou& Yu, Janchun& Zhu, Aiqin& Nakanishi, Hiroshi. 2016. Nutrients, Microglia Aging, and Brain Aging. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114202
Modern Language Association (MLA)
Wu, Zhou…[et al.]. Nutrients, Microglia Aging, and Brain Aging. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114202
American Medical Association (AMA)
Wu, Zhou& Yu, Janchun& Zhu, Aiqin& Nakanishi, Hiroshi. Nutrients, Microglia Aging, and Brain Aging. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114202
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114202