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Identification of MicroRNAs Involved in Growth Arrest and Apoptosis in Hydrogen Peroxide-Treated Human Hepatocellular Carcinoma Cell Line HepG2
المؤلفون المشاركون
Zhang, Chun-yan
Tian, Ya-Ping
Zhang, Pengjun
Luo, Yuan
Wen, Xinyu
Wang, Ling
Gao, Jing
Wang, Zi
Lu, Chengrong
Duan, Lianning
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-15
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Although both oxidative stress and microRNAs (miRNAs) play vital roles in physiological and pathological processes, little is known about the interactions between them.
In this study, we first described the regulation of H2O2 in cell viability, proliferation, cycle, and apoptosis of human hepatocellular carcinoma cell line HepG2.
Then, miRNAs expression was profiled after H2O2 treatment.
The results showed that high concentration of H2O2 (600 μM) could decrease cell viability, inhibit cell proliferation, induce cell cycle arrest, and finally promote cell apoptosis.
Conversely, no significant effects could be found under treatment with low concentration (30 μM).
miRNAs array analysis identified 131 differentially expressed miRNAs (125 were upregulated and 6 were downregulated) and predicted 13504 putative target genes of the deregulated miRNAs.
Gene ontology (GO) analysis revealed that the putative target genes were associated with H2O2-induced cell growth arrest and apoptosis.
The subsequent bioinformatics analysis indicated that H2O2-response pathways, including MAPK signaling pathway, apoptosis, and pathways in cancer and cell cycle, were significantly affected.
Overall, these results provided comprehensive information on the biological function of H2O2 treatment in HepG2 cells.
The identification of miRNAs and their putative targets may offer new diagnostic and therapeutic strategies for liver cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luo, Yuan& Wen, Xinyu& Wang, Ling& Gao, Jing& Wang, Zi& Zhang, Chun-yan…[et al.]. 2016. Identification of MicroRNAs Involved in Growth Arrest and Apoptosis in Hydrogen Peroxide-Treated Human Hepatocellular Carcinoma Cell Line HepG2. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114209
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luo, Yuan…[et al.]. Identification of MicroRNAs Involved in Growth Arrest and Apoptosis in Hydrogen Peroxide-Treated Human Hepatocellular Carcinoma Cell Line HepG2. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114209
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luo, Yuan& Wen, Xinyu& Wang, Ling& Gao, Jing& Wang, Zi& Zhang, Chun-yan…[et al.]. Identification of MicroRNAs Involved in Growth Arrest and Apoptosis in Hydrogen Peroxide-Treated Human Hepatocellular Carcinoma Cell Line HepG2. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114209
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114209
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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