![](/images/graphics-bg.png)
Correlation between Mitochondrial Reactive Oxygen and Severity of Atherosclerosis
المؤلفون المشاركون
Vercesi, Anibal E.
Dorighello, Gabriel G.
Paim, Bruno A.
Kiihl, Samara F.
Ferreira, Mônica S.
Catharino, Rodrigo R.
Oliveira, Helena C. F.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Atherosclerosis has been associated with mitochondria dysfunction and damage.
Our group demonstrated previously that hypercholesterolemic mice present increased mitochondrial reactive oxygen (mtROS) generation in several tissues and low NADPH/NADP+ ratio.
Here, we investigated whether spontaneous atherosclerosis in these mice could be modulated by treatments that replenish or spare mitochondrial NADPH, named citrate supplementation, cholesterol synthesis inhibition, or both treatments simultaneously.
Robust statistical analyses in pooled group data were performed in order to explain the variation of atherosclerosis lesion areas as related to the classic atherosclerosis risk factors such as plasma lipids, obesity, and oxidative stress, including liver mtROS.
Using three distinct statistical tools (univariate correlation, adjusted correlation, and multiple regression) with increasing levels of stringency, we identified a novel significant association and a model that reliably predicts the extent of atherosclerosis due to variations in mtROS.
Thus, results show that atherosclerosis lesion area is positively and independently correlated with liver mtROS production rates.
Based on these findings, we propose that modulation of mitochondrial redox state influences the atherosclerosis extent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dorighello, Gabriel G.& Paim, Bruno A.& Kiihl, Samara F.& Ferreira, Mônica S.& Catharino, Rodrigo R.& Vercesi, Anibal E.…[et al.]. 2015. Correlation between Mitochondrial Reactive Oxygen and Severity of Atherosclerosis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114245
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dorighello, Gabriel G.…[et al.]. Correlation between Mitochondrial Reactive Oxygen and Severity of Atherosclerosis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114245
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dorighello, Gabriel G.& Paim, Bruno A.& Kiihl, Samara F.& Ferreira, Mônica S.& Catharino, Rodrigo R.& Vercesi, Anibal E.…[et al.]. Correlation between Mitochondrial Reactive Oxygen and Severity of Atherosclerosis. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114245
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114245
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)