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Correlation between Mitochondrial Reactive Oxygen and Severity of Atherosclerosis
Joint Authors
Vercesi, Anibal E.
Dorighello, Gabriel G.
Paim, Bruno A.
Kiihl, Samara F.
Ferreira, Mônica S.
Catharino, Rodrigo R.
Oliveira, Helena C. F.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Atherosclerosis has been associated with mitochondria dysfunction and damage.
Our group demonstrated previously that hypercholesterolemic mice present increased mitochondrial reactive oxygen (mtROS) generation in several tissues and low NADPH/NADP+ ratio.
Here, we investigated whether spontaneous atherosclerosis in these mice could be modulated by treatments that replenish or spare mitochondrial NADPH, named citrate supplementation, cholesterol synthesis inhibition, or both treatments simultaneously.
Robust statistical analyses in pooled group data were performed in order to explain the variation of atherosclerosis lesion areas as related to the classic atherosclerosis risk factors such as plasma lipids, obesity, and oxidative stress, including liver mtROS.
Using three distinct statistical tools (univariate correlation, adjusted correlation, and multiple regression) with increasing levels of stringency, we identified a novel significant association and a model that reliably predicts the extent of atherosclerosis due to variations in mtROS.
Thus, results show that atherosclerosis lesion area is positively and independently correlated with liver mtROS production rates.
Based on these findings, we propose that modulation of mitochondrial redox state influences the atherosclerosis extent.
American Psychological Association (APA)
Dorighello, Gabriel G.& Paim, Bruno A.& Kiihl, Samara F.& Ferreira, Mônica S.& Catharino, Rodrigo R.& Vercesi, Anibal E.…[et al.]. 2015. Correlation between Mitochondrial Reactive Oxygen and Severity of Atherosclerosis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114245
Modern Language Association (MLA)
Dorighello, Gabriel G.…[et al.]. Correlation between Mitochondrial Reactive Oxygen and Severity of Atherosclerosis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114245
American Medical Association (AMA)
Dorighello, Gabriel G.& Paim, Bruno A.& Kiihl, Samara F.& Ferreira, Mônica S.& Catharino, Rodrigo R.& Vercesi, Anibal E.…[et al.]. Correlation between Mitochondrial Reactive Oxygen and Severity of Atherosclerosis. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114245