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Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation
المؤلفون المشاركون
Wen, Tao
Liu, Fuquan
Liu, Xiaowei
He, Haiyue
Huang, Tingting
Lei, Zhen
An, Guangyu
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Neutrophils play a critical role in the initiation and maintenance of intestinal inflammation.
However, conventional neutrophil-targeted therapies can impair normal host defense.
Tanshinone IIA has been recently revealed to act directly on neutrophils.
Hence, we aimed at investigating whether Tanshinone IIA can protect against experimental colitis through modulation of neutrophils.
We induced colitis in C57BL/6 mice by giving 3% dextran sulfate sodium (DSS) orally, and meanwhile, we treated mice daily with Tanshinone IIA intraperitoneally.
The severity of colitis was evaluated by calculating disease activity index (DAI) and histological parameters.
Neutrophil infiltration and activation in the colons of mice were measured.
Moreover, whether Tanshinone IIA has direct effects on neutrophil migration and activation was determined in vitro.
Our data showed that Tanshinone IIA significantly ameliorated the severity of DSS-induced colitis in mice, evidenced by the reduced DAI and improved colonic inflammation.
In addition, Tanshinone IIA decreased neutrophil infiltration of intestinal mucosa and activation and reduced colonic inflammatory cytokines in DSS-treated mice.
Furthermore, Tanshinone IIA was demonstrated to significantly suppress neutrophil migration and activation.
These results provide compelling evidence that Tanshinone IIA has a therapeutic potential for alleviating inflammatory colitis in mice, which is possibly mediated by the immunomodulation of neutrophils.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Xiaowei& He, Haiyue& Huang, Tingting& Lei, Zhen& Liu, Fuquan& An, Guangyu…[et al.]. 2016. Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114262
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Xiaowei…[et al.]. Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114262
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Xiaowei& He, Haiyue& Huang, Tingting& Lei, Zhen& Liu, Fuquan& An, Guangyu…[et al.]. Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114262
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114262
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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