Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation
Joint Authors
Wen, Tao
Liu, Fuquan
Liu, Xiaowei
He, Haiyue
Huang, Tingting
Lei, Zhen
An, Guangyu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Neutrophils play a critical role in the initiation and maintenance of intestinal inflammation.
However, conventional neutrophil-targeted therapies can impair normal host defense.
Tanshinone IIA has been recently revealed to act directly on neutrophils.
Hence, we aimed at investigating whether Tanshinone IIA can protect against experimental colitis through modulation of neutrophils.
We induced colitis in C57BL/6 mice by giving 3% dextran sulfate sodium (DSS) orally, and meanwhile, we treated mice daily with Tanshinone IIA intraperitoneally.
The severity of colitis was evaluated by calculating disease activity index (DAI) and histological parameters.
Neutrophil infiltration and activation in the colons of mice were measured.
Moreover, whether Tanshinone IIA has direct effects on neutrophil migration and activation was determined in vitro.
Our data showed that Tanshinone IIA significantly ameliorated the severity of DSS-induced colitis in mice, evidenced by the reduced DAI and improved colonic inflammation.
In addition, Tanshinone IIA decreased neutrophil infiltration of intestinal mucosa and activation and reduced colonic inflammatory cytokines in DSS-treated mice.
Furthermore, Tanshinone IIA was demonstrated to significantly suppress neutrophil migration and activation.
These results provide compelling evidence that Tanshinone IIA has a therapeutic potential for alleviating inflammatory colitis in mice, which is possibly mediated by the immunomodulation of neutrophils.
American Psychological Association (APA)
Liu, Xiaowei& He, Haiyue& Huang, Tingting& Lei, Zhen& Liu, Fuquan& An, Guangyu…[et al.]. 2016. Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114262
Modern Language Association (MLA)
Liu, Xiaowei…[et al.]. Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114262
American Medical Association (AMA)
Liu, Xiaowei& He, Haiyue& Huang, Tingting& Lei, Zhen& Liu, Fuquan& An, Guangyu…[et al.]. Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114262