Liver Damage in Patients with HCVHIV Coinfection Is Linked to HIV-Related Oxidative Stress
المؤلفون المشاركون
Huang, Xiangbo
Liang, Hua
Fan, Xueying
Zhu, Liyan
Shen, Tao
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
HIV infection aggravates the progression of liver damage in HCV-coinfected patients, with the underlying pathogenesis being multifactorial.
Although high level of oxidative stress has been observed frequently in patients infected with HIV or HCV, the status of oxidative stress in HIV/HCV coinfection and its contribution to HCV liver damage have not been determined.
This study involved 363 HBsAg-negative, anti-HCV-positive former blood donors recruited from a village in central China in July 2005; of these, 140 were positive for HIV.
Of these 363 subjects, 282 were successfully followed up through July 2009.
HIV/HCV-coinfected subjects had higher rates of end-stage liver disease-related death than those monoinfected with HCV.
Liver ultrasound manifestations were poor in HIV-positive than in HIV-negative individuals, in both chronic HCV carriers and those with resolved HCV.
Serum concentrations of total glutathione (tGSH), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), GSSG, and reduced GSH were higher in HIV-positive than HIV-negative subjects.
GSSG concentrations were higher in HIV-infected subjects with abnormal ALT/AST levels than in those with normal ALT/AST levels and were associated with poorer liver ultrasound manifestations.
These finding indicated that HIV infection accelerated HCV-associated liver damage in HIV/HCV-coinfected individuals.
Increased oxidative stress, induced primarily by HIV coinfection, may contribute to aggravated liver damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Xiangbo& Liang, Hua& Fan, Xueying& Zhu, Liyan& Shen, Tao. 2016. Liver Damage in Patients with HCVHIV Coinfection Is Linked to HIV-Related Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114292
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Xiangbo…[et al.]. Liver Damage in Patients with HCVHIV Coinfection Is Linked to HIV-Related Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114292
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Xiangbo& Liang, Hua& Fan, Xueying& Zhu, Liyan& Shen, Tao. Liver Damage in Patients with HCVHIV Coinfection Is Linked to HIV-Related Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114292
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114292
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر