Liver Damage in Patients with HCVHIV Coinfection Is Linked to HIV-Related Oxidative Stress
Joint Authors
Huang, Xiangbo
Liang, Hua
Fan, Xueying
Zhu, Liyan
Shen, Tao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
HIV infection aggravates the progression of liver damage in HCV-coinfected patients, with the underlying pathogenesis being multifactorial.
Although high level of oxidative stress has been observed frequently in patients infected with HIV or HCV, the status of oxidative stress in HIV/HCV coinfection and its contribution to HCV liver damage have not been determined.
This study involved 363 HBsAg-negative, anti-HCV-positive former blood donors recruited from a village in central China in July 2005; of these, 140 were positive for HIV.
Of these 363 subjects, 282 were successfully followed up through July 2009.
HIV/HCV-coinfected subjects had higher rates of end-stage liver disease-related death than those monoinfected with HCV.
Liver ultrasound manifestations were poor in HIV-positive than in HIV-negative individuals, in both chronic HCV carriers and those with resolved HCV.
Serum concentrations of total glutathione (tGSH), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), GSSG, and reduced GSH were higher in HIV-positive than HIV-negative subjects.
GSSG concentrations were higher in HIV-infected subjects with abnormal ALT/AST levels than in those with normal ALT/AST levels and were associated with poorer liver ultrasound manifestations.
These finding indicated that HIV infection accelerated HCV-associated liver damage in HIV/HCV-coinfected individuals.
Increased oxidative stress, induced primarily by HIV coinfection, may contribute to aggravated liver damage.
American Psychological Association (APA)
Huang, Xiangbo& Liang, Hua& Fan, Xueying& Zhu, Liyan& Shen, Tao. 2016. Liver Damage in Patients with HCVHIV Coinfection Is Linked to HIV-Related Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114292
Modern Language Association (MLA)
Huang, Xiangbo…[et al.]. Liver Damage in Patients with HCVHIV Coinfection Is Linked to HIV-Related Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114292
American Medical Association (AMA)
Huang, Xiangbo& Liang, Hua& Fan, Xueying& Zhu, Liyan& Shen, Tao. Liver Damage in Patients with HCVHIV Coinfection Is Linked to HIV-Related Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114292