Cardioprotective Effects of Astragalin against Myocardial IschemiaReperfusion Injury in Isolated Rat Heart
المؤلفون المشاركون
Zheng, Qiusheng
Wang, Dong
Han, Jichun
Ren, Huanhuan
Qu, Daoxu
Yang, Wenxiao
Zhang, Xinjie
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-16
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This study aims to evaluate the cardioprotective effects of astragalin against myocardial ischemia/reperfusion (I/R) injury in isolated rat heart.
The cardioprotective effects of astragalin on myocardial I/R injury were investigated on Langendorff apparatus.
Adult male Sprague-Dawley rats were randomly divided into five groups.
The results showed that astragalin pretreatment improved myocardial function.
Compared with I/R group, lactate dehydrogenase (LDH) and creatine kinase (CK) activities in coronary flow decreased in astragalin pretreatment groups, whereas superoxide dismutase (SOD) activity and glutathione/glutathione disulfide (GSH/GSSG) ratio significantly increased.
The levels of malondialdehyde (MDA), intracellular reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) decreased in astragalin-treated groups.
The infarct size (IS) and apoptosis rate in hearts from astragalin-treated groups were lower than those in hearts from the I/R group.
Western blot analysis also revealed that astragalin preconditioning significantly reduced Bax level, whereas Bcl-2 was increased in the myocardium.
Therefore, astragalin exhibited cardioprotective effects via its antioxidative, antiapoptotic, and anti-inflammatory activities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qu, Daoxu& Han, Jichun& Ren, Huanhuan& Yang, Wenxiao& Zhang, Xinjie& Zheng, Qiusheng…[et al.]. 2015. Cardioprotective Effects of Astragalin against Myocardial IschemiaReperfusion Injury in Isolated Rat Heart. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114296
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qu, Daoxu…[et al.]. Cardioprotective Effects of Astragalin against Myocardial IschemiaReperfusion Injury in Isolated Rat Heart. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114296
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qu, Daoxu& Han, Jichun& Ren, Huanhuan& Yang, Wenxiao& Zhang, Xinjie& Zheng, Qiusheng…[et al.]. Cardioprotective Effects of Astragalin against Myocardial IschemiaReperfusion Injury in Isolated Rat Heart. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114296
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114296
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر