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Cardioprotective Effects of Astragalin against Myocardial IschemiaReperfusion Injury in Isolated Rat Heart
Joint Authors
Zheng, Qiusheng
Wang, Dong
Han, Jichun
Ren, Huanhuan
Qu, Daoxu
Yang, Wenxiao
Zhang, Xinjie
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study aims to evaluate the cardioprotective effects of astragalin against myocardial ischemia/reperfusion (I/R) injury in isolated rat heart.
The cardioprotective effects of astragalin on myocardial I/R injury were investigated on Langendorff apparatus.
Adult male Sprague-Dawley rats were randomly divided into five groups.
The results showed that astragalin pretreatment improved myocardial function.
Compared with I/R group, lactate dehydrogenase (LDH) and creatine kinase (CK) activities in coronary flow decreased in astragalin pretreatment groups, whereas superoxide dismutase (SOD) activity and glutathione/glutathione disulfide (GSH/GSSG) ratio significantly increased.
The levels of malondialdehyde (MDA), intracellular reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) decreased in astragalin-treated groups.
The infarct size (IS) and apoptosis rate in hearts from astragalin-treated groups were lower than those in hearts from the I/R group.
Western blot analysis also revealed that astragalin preconditioning significantly reduced Bax level, whereas Bcl-2 was increased in the myocardium.
Therefore, astragalin exhibited cardioprotective effects via its antioxidative, antiapoptotic, and anti-inflammatory activities.
American Psychological Association (APA)
Qu, Daoxu& Han, Jichun& Ren, Huanhuan& Yang, Wenxiao& Zhang, Xinjie& Zheng, Qiusheng…[et al.]. 2015. Cardioprotective Effects of Astragalin against Myocardial IschemiaReperfusion Injury in Isolated Rat Heart. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114296
Modern Language Association (MLA)
Qu, Daoxu…[et al.]. Cardioprotective Effects of Astragalin against Myocardial IschemiaReperfusion Injury in Isolated Rat Heart. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114296
American Medical Association (AMA)
Qu, Daoxu& Han, Jichun& Ren, Huanhuan& Yang, Wenxiao& Zhang, Xinjie& Zheng, Qiusheng…[et al.]. Cardioprotective Effects of Astragalin against Myocardial IschemiaReperfusion Injury in Isolated Rat Heart. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114296