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The Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effects
المؤلفون المشاركون
Damião, Marcio José
Carollo, Carlos Alexandre
Campos, Jaqueline Ferreira
de Picoli Souza, Kely
Santos, Edson Lucas dos
de Castro, David Tsuyoshi Hiramatsu
Vieira Torquato, Heron F.
Paredes-Gamero, Edgar J.
Miranda Fernandes Estevinho, M. L.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Natural products can be a source of biomolecules with antioxidant activity which are able to prevent oxidative stress-induced diseases and show antitumor activity, making them important sources of new anticancer drug prototypes.
In this context, this study aimed to analyze the chemical composition of an ethanol extract of Senna velutina leaves and to assess its antioxidant and cytotoxic activities in leukemic cells.
The antioxidant properties were evaluated using a DPPH free radical scavenging assay and by examining the extract’s inhibition of AAPH-induced lipid peroxidation in human erythrocytes.
Its cytotoxicity and possible mechanisms of action were assessed in Jurkat and K562 leukemic cell lines.
The ethanol extract contained flavonoids, such as epigallocatechin, epicatechin, kaempferol heteroside, rutin, and dimeric and trimeric proanthocyanidin derivatives.
The extract exhibited antioxidant activity by scavenging free radicals and antihemolytic action, and it decreased malondialdehyde content in human erythrocytes.
Furthermore, the extract also induced leukemic cell death by activating intracellular calcium and caspase-3, decreasing mitochondrial membrane potential, and arresting the cell cycle in S and G2 phases.
Hence, S.
velutina leaf extract contains antioxidant and antileukemic biomolecules with potential applications in diseases associated with oxidative stress and in the inhibition of tumor cell proliferation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Campos, Jaqueline Ferreira& de Castro, David Tsuyoshi Hiramatsu& Damião, Marcio José& Vieira Torquato, Heron F.& Paredes-Gamero, Edgar J.& Carollo, Carlos Alexandre…[et al.]. 2016. The Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effects. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114360
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Campos, Jaqueline Ferreira…[et al.]. The Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effects. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1114360
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Campos, Jaqueline Ferreira& de Castro, David Tsuyoshi Hiramatsu& Damião, Marcio José& Vieira Torquato, Heron F.& Paredes-Gamero, Edgar J.& Carollo, Carlos Alexandre…[et al.]. The Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effects. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114360
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114360
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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