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The Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effects
Joint Authors
Damião, Marcio José
Carollo, Carlos Alexandre
Campos, Jaqueline Ferreira
de Picoli Souza, Kely
Santos, Edson Lucas dos
de Castro, David Tsuyoshi Hiramatsu
Vieira Torquato, Heron F.
Paredes-Gamero, Edgar J.
Miranda Fernandes Estevinho, M. L.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Natural products can be a source of biomolecules with antioxidant activity which are able to prevent oxidative stress-induced diseases and show antitumor activity, making them important sources of new anticancer drug prototypes.
In this context, this study aimed to analyze the chemical composition of an ethanol extract of Senna velutina leaves and to assess its antioxidant and cytotoxic activities in leukemic cells.
The antioxidant properties were evaluated using a DPPH free radical scavenging assay and by examining the extract’s inhibition of AAPH-induced lipid peroxidation in human erythrocytes.
Its cytotoxicity and possible mechanisms of action were assessed in Jurkat and K562 leukemic cell lines.
The ethanol extract contained flavonoids, such as epigallocatechin, epicatechin, kaempferol heteroside, rutin, and dimeric and trimeric proanthocyanidin derivatives.
The extract exhibited antioxidant activity by scavenging free radicals and antihemolytic action, and it decreased malondialdehyde content in human erythrocytes.
Furthermore, the extract also induced leukemic cell death by activating intracellular calcium and caspase-3, decreasing mitochondrial membrane potential, and arresting the cell cycle in S and G2 phases.
Hence, S.
velutina leaf extract contains antioxidant and antileukemic biomolecules with potential applications in diseases associated with oxidative stress and in the inhibition of tumor cell proliferation.
American Psychological Association (APA)
Campos, Jaqueline Ferreira& de Castro, David Tsuyoshi Hiramatsu& Damião, Marcio José& Vieira Torquato, Heron F.& Paredes-Gamero, Edgar J.& Carollo, Carlos Alexandre…[et al.]. 2016. The Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effects. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114360
Modern Language Association (MLA)
Campos, Jaqueline Ferreira…[et al.]. The Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effects. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1114360
American Medical Association (AMA)
Campos, Jaqueline Ferreira& de Castro, David Tsuyoshi Hiramatsu& Damião, Marcio José& Vieira Torquato, Heron F.& Paredes-Gamero, Edgar J.& Carollo, Carlos Alexandre…[et al.]. The Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effects. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114360