![](/images/graphics-bg.png)
The Tumorigenic Roles of the Cellular REDOX Regulatory Systems
المؤلفون المشاركون
Madureira, Patrícia Alexandra
Castaldo, Stéphanie Anaís
Freitas, Joana Raquel
Conchinha, Nadine Vasconcelos
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-22
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
The cellular REDOX regulatory systems play a central role in maintaining REDOX homeostasis that is crucial for cell integrity, survival, and proliferation.
To date, a substantial amount of data has demonstrated that cancer cells typically undergo increasing oxidative stress as the tumor develops, upregulating these important antioxidant systems in order to survive, proliferate, and metastasize under these extreme oxidative stress conditions.
Since a large number of chemotherapeutic agents currently used in the clinic rely on the induction of ROS overload or change of ROS quality to kill the tumor, the cancer cell REDOX adaptation represents a significant obstacle to conventional chemotherapy.
In this review we will first examine the different factors that contribute to the enhanced oxidative stress generally observed within the tumor microenvironment.
We will then make a comprehensive assessment of the current literature regarding the main antioxidant proteins and systems that have been shown to be positively associated with tumor progression and chemoresistance.
Finally we will make an analysis of commonly used chemotherapeutic drugs that induce ROS.
The current knowledge of cancer cell REDOX adaptation raises the issue of developing novel and more effective therapies for these tumors that are usually resistant to conventional ROS inducing chemotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Castaldo, Stéphanie Anaís& Freitas, Joana Raquel& Conchinha, Nadine Vasconcelos& Madureira, Patrícia Alexandra. 2015. The Tumorigenic Roles of the Cellular REDOX Regulatory Systems. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1114364
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Castaldo, Stéphanie Anaís…[et al.]. The Tumorigenic Roles of the Cellular REDOX Regulatory Systems. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1114364
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Castaldo, Stéphanie Anaís& Freitas, Joana Raquel& Conchinha, Nadine Vasconcelos& Madureira, Patrícia Alexandra. The Tumorigenic Roles of the Cellular REDOX Regulatory Systems. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1114364
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114364
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)