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The Tumorigenic Roles of the Cellular REDOX Regulatory Systems
Joint Authors
Madureira, Patrícia Alexandra
Castaldo, Stéphanie Anaís
Freitas, Joana Raquel
Conchinha, Nadine Vasconcelos
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-22
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The cellular REDOX regulatory systems play a central role in maintaining REDOX homeostasis that is crucial for cell integrity, survival, and proliferation.
To date, a substantial amount of data has demonstrated that cancer cells typically undergo increasing oxidative stress as the tumor develops, upregulating these important antioxidant systems in order to survive, proliferate, and metastasize under these extreme oxidative stress conditions.
Since a large number of chemotherapeutic agents currently used in the clinic rely on the induction of ROS overload or change of ROS quality to kill the tumor, the cancer cell REDOX adaptation represents a significant obstacle to conventional chemotherapy.
In this review we will first examine the different factors that contribute to the enhanced oxidative stress generally observed within the tumor microenvironment.
We will then make a comprehensive assessment of the current literature regarding the main antioxidant proteins and systems that have been shown to be positively associated with tumor progression and chemoresistance.
Finally we will make an analysis of commonly used chemotherapeutic drugs that induce ROS.
The current knowledge of cancer cell REDOX adaptation raises the issue of developing novel and more effective therapies for these tumors that are usually resistant to conventional ROS inducing chemotherapy.
American Psychological Association (APA)
Castaldo, Stéphanie Anaís& Freitas, Joana Raquel& Conchinha, Nadine Vasconcelos& Madureira, Patrícia Alexandra. 2015. The Tumorigenic Roles of the Cellular REDOX Regulatory Systems. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1114364
Modern Language Association (MLA)
Castaldo, Stéphanie Anaís…[et al.]. The Tumorigenic Roles of the Cellular REDOX Regulatory Systems. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1114364
American Medical Association (AMA)
Castaldo, Stéphanie Anaís& Freitas, Joana Raquel& Conchinha, Nadine Vasconcelos& Madureira, Patrícia Alexandra. The Tumorigenic Roles of the Cellular REDOX Regulatory Systems. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1114364
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114364