Experimental Colitis Is Attenuated by Cardioprotective Diet Supplementation That Reduces Oxidative Stress, Inflammation, and Mucosal Damage
المؤلفون المشاركون
Schnoor, Michael
Vargas-Robles, Hilda
Citalán Madrid, Alí Francisco
García Ponce, Alexander
Silva Olivares, Angelica
Betanzos, Abigail
Del Valle Mondragón, Leonardo
Nava, Porfirio
Shibayama, Mineko
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn’s disease (CD) are multifactorial, relapsing disorders of the gastrointestinal tract.
However, the etiology is still poorly understood but involves altered immune responses, epithelial dysfunction, environmental factors, and nutrition.
Recently, we have shown that the diet supplement corabion has cardioprotective effects due to reduction of oxidative stress and inflammation.
Since oxidative stress and inflammation are also prominent risk factors in IBD, we speculated that corabion also has beneficial effects on experimental colitis.
Colitis was induced in male mice by administration of 3.5% (w/v) dextran sulfate sodium (DSS) in drinking water for a period of 3 or 7 days with or without daily gavage feeding of corabion consisting of vitamin C, vitamin E, L-arginine, and eicosapentaenoic and docosahexaenoic acid.
We found that corabion administration attenuated DSS-induced colon shortening, tissue damage, and disease activity index during the onset of colitis.
Mechanistically, these effects could be explained by reduced neutrophil recruitment, oxidative stress, production of proinflammatory cytokines, and internalization of the junctional proteins ZO-1 and E-cadherin leading to less edema formation.
Thus, corabion may be a useful diet supplement for the management of chronic inflammatory intestinal disorders such as IBD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vargas-Robles, Hilda& Citalán Madrid, Alí Francisco& García Ponce, Alexander& Silva Olivares, Angelica& Shibayama, Mineko& Betanzos, Abigail…[et al.]. 2016. Experimental Colitis Is Attenuated by Cardioprotective Diet Supplementation That Reduces Oxidative Stress, Inflammation, and Mucosal Damage. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114372
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vargas-Robles, Hilda…[et al.]. Experimental Colitis Is Attenuated by Cardioprotective Diet Supplementation That Reduces Oxidative Stress, Inflammation, and Mucosal Damage. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114372
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vargas-Robles, Hilda& Citalán Madrid, Alí Francisco& García Ponce, Alexander& Silva Olivares, Angelica& Shibayama, Mineko& Betanzos, Abigail…[et al.]. Experimental Colitis Is Attenuated by Cardioprotective Diet Supplementation That Reduces Oxidative Stress, Inflammation, and Mucosal Damage. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114372
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114372
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر