Experimental Colitis Is Attenuated by Cardioprotective Diet Supplementation That Reduces Oxidative Stress, Inflammation, and Mucosal Damage
Joint Authors
Schnoor, Michael
Vargas-Robles, Hilda
Citalán Madrid, Alí Francisco
García Ponce, Alexander
Silva Olivares, Angelica
Betanzos, Abigail
Del Valle Mondragón, Leonardo
Nava, Porfirio
Shibayama, Mineko
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn’s disease (CD) are multifactorial, relapsing disorders of the gastrointestinal tract.
However, the etiology is still poorly understood but involves altered immune responses, epithelial dysfunction, environmental factors, and nutrition.
Recently, we have shown that the diet supplement corabion has cardioprotective effects due to reduction of oxidative stress and inflammation.
Since oxidative stress and inflammation are also prominent risk factors in IBD, we speculated that corabion also has beneficial effects on experimental colitis.
Colitis was induced in male mice by administration of 3.5% (w/v) dextran sulfate sodium (DSS) in drinking water for a period of 3 or 7 days with or without daily gavage feeding of corabion consisting of vitamin C, vitamin E, L-arginine, and eicosapentaenoic and docosahexaenoic acid.
We found that corabion administration attenuated DSS-induced colon shortening, tissue damage, and disease activity index during the onset of colitis.
Mechanistically, these effects could be explained by reduced neutrophil recruitment, oxidative stress, production of proinflammatory cytokines, and internalization of the junctional proteins ZO-1 and E-cadherin leading to less edema formation.
Thus, corabion may be a useful diet supplement for the management of chronic inflammatory intestinal disorders such as IBD.
American Psychological Association (APA)
Vargas-Robles, Hilda& Citalán Madrid, Alí Francisco& García Ponce, Alexander& Silva Olivares, Angelica& Shibayama, Mineko& Betanzos, Abigail…[et al.]. 2016. Experimental Colitis Is Attenuated by Cardioprotective Diet Supplementation That Reduces Oxidative Stress, Inflammation, and Mucosal Damage. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114372
Modern Language Association (MLA)
Vargas-Robles, Hilda…[et al.]. Experimental Colitis Is Attenuated by Cardioprotective Diet Supplementation That Reduces Oxidative Stress, Inflammation, and Mucosal Damage. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114372
American Medical Association (AMA)
Vargas-Robles, Hilda& Citalán Madrid, Alí Francisco& García Ponce, Alexander& Silva Olivares, Angelica& Shibayama, Mineko& Betanzos, Abigail…[et al.]. Experimental Colitis Is Attenuated by Cardioprotective Diet Supplementation That Reduces Oxidative Stress, Inflammation, and Mucosal Damage. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114372