![](/images/graphics-bg.png)
Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model
المؤلفون المشاركون
Keller, Amy C.
Knaub, Leslie A.
McClatchey, P. Mason
Connon, Chelsea A.
Bouchard, Ron
Miller, Matthew W.
Geary, Kate E.
Walker, Lori A.
Klemm, Dwight J.
Reusch, Jane E. B.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-11
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Diabetes affects more than 330 million people worldwide and causes elevated cardiovascular disease risk.
Mitochondria are critical for vascular function, generate cellular reactive oxygen species (ROS), and are perturbed by diabetes, representing a novel target for therapeutics.
We hypothesized that adaptive mitochondrial plasticity in response to nutrient stress would be impaired in diabetes cellular physiology via a nitric oxide synthase- (NOS-) mediated decrease in mitochondrial function.
Primary smooth muscle cells (SMCs) from aorta of the nonobese, insulin resistant rat diabetes model Goto-Kakizaki (GK) and the Wistar control rat were exposed to high glucose (25 mM).
At baseline, significantly greater nitric oxide evolution, ROS production, and respiratory control ratio (RCR) were observed in GK SMCs.
Upon exposure to high glucose, expression of phosphorylated eNOS, uncoupled respiration, and expression of mitochondrial complexes I, II, III, and V were significantly decreased in GK SMCs (p<0.05).
Mitochondrial superoxide increased with high glucose in Wistar SMCs (p<0.05) with no change in the GK beyond elevated baseline concentrations.
Baseline comparisons show persistent metabolic perturbations in a diabetes phenotype.
Overall, nutrient stress in GK SMCs caused a persistent decline in eNOS and mitochondrial function and disrupted mitochondrial plasticity, illustrating eNOS and mitochondria as potential therapeutic targets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Keller, Amy C.& Knaub, Leslie A.& McClatchey, P. Mason& Connon, Chelsea A.& Bouchard, Ron& Miller, Matthew W.…[et al.]. 2016. Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1114384
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Keller, Amy C.…[et al.]. Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1114384
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Keller, Amy C.& Knaub, Leslie A.& McClatchey, P. Mason& Connon, Chelsea A.& Bouchard, Ron& Miller, Matthew W.…[et al.]. Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1114384
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114384
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)