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Characteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice
المؤلفون المشاركون
Nagahisa, Hiroshi
Miyata, Hirofumi
Okabe, Kazuma
Iuchi, Yoshihito
Fujii, Junichi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cu/Zn superoxide dismutase (SOD1) knockout (KO) mice are known as an aging model in some aspects, but the damage and regeneration process of each fiber type have not been sufficiently studied.
In this study, we investigated the damage and satellite cell state of the gastrocnemius muscle in SOD1 KO mice (6 months old) using immunohistochemical staining and real-time RT-PCR.
The proportion of central nuclei-containing Type IIx/b fibers in the deep and superficial portions of the gastrocnemius muscle was significantly higher in SOD1 KO than control mice.
The number of satellite cells per muscle fiber decreased in all muscle fiber types in the deep portion of the gastrocnemius muscle in SOD1 KO mice.
In addition, the mRNA expression levels of Pax7 and myogenin, which are expressed in satellite cells in the activation, proliferation, and differentiation states, significantly increased in the gastrocnemius muscle of SOD1 KO mice.
Furthermore, mRNA of myosin heavy chain-embryonic, which is expressed in the early phase of muscle regeneration, significantly increased in SOD1 KO mice.
It was suggested that muscle is damaged by reactive oxygen species produced in the mitochondrial intermembrane space in Type IIxb fibers, accelerating the proliferation and differentiation of satellite cells through growth factors in SOD1 KO mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nagahisa, Hiroshi& Okabe, Kazuma& Iuchi, Yoshihito& Fujii, Junichi& Miyata, Hirofumi. 2015. Characteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114754
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nagahisa, Hiroshi…[et al.]. Characteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114754
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nagahisa, Hiroshi& Okabe, Kazuma& Iuchi, Yoshihito& Fujii, Junichi& Miyata, Hirofumi. Characteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114754
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114754
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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