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Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract of Curatella americana L. Leaves
المؤلفون المشاركون
Rocha, Paola dos Santos da
de Picoli Souza, Kely
Antunes, Kátia Avila
dos Santos, Edson Lucas
Espindola, Priscilla Pereira de Toledo
Pereira, Zefa Valdivina
Lopes, Rafael Henrique Oliveira
Macorini, Luis Fernando Benitez
Alfredo, Tamaeh Monteiro
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
High levels of reactive oxygen species in the body and hyperlipidemia are key factors for the development of cardiovascular diseases such as atherosclerosis.
The present study investigated the antioxidant and hypolipidemic activity of hydroethanolic extract of Curatella americana L.
leaves (ExC).
The antioxidant activity of ExC was assessed by 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) scavenging capacity and protection against hemolysis induced by 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH), followed by quantification of malondialdehyde (MDA).
Wistar rats with hyperlipidemia induced by high-fructose diet (60%) were treated for 60 days with water, simvastatin (30 mg·Kg−1), ciprofibrate (2 mg·Kg−1), and ExC (200 mg·Kg−1).
ExC revealed IC50 of 6.0 ± 0.5 μg·mL−1, an intermediary value among positive controls used in the assay of DPPH scavenging capacity.
At all concentrations (50 to 125 μg·mL−1) and times (60 to 240 min) evaluated, ExC protected erythrocytes against AAPH-induced hemolysis, which was confirmed by lower MDA levels.
In vivo tests showed a reduction of 34 and 45%, respectively, in serum concentration of cholesterol and triglycerides in hyperlipidemic rats treated with ExC, a similar effect compared to the reference drugs, simvastatin and ciprofibrate, respectively.
Together, the results showed the antioxidant activity of ExC and its ability to improve the serum lipid profile in hyperlipidemic rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lopes, Rafael Henrique Oliveira& Macorini, Luis Fernando Benitez& Antunes, Kátia Avila& Espindola, Priscilla Pereira de Toledo& Alfredo, Tamaeh Monteiro& Rocha, Paola dos Santos da…[et al.]. 2016. Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract of Curatella americana L. Leaves. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114804
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lopes, Rafael Henrique Oliveira…[et al.]. Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract of Curatella americana L. Leaves. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1114804
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lopes, Rafael Henrique Oliveira& Macorini, Luis Fernando Benitez& Antunes, Kátia Avila& Espindola, Priscilla Pereira de Toledo& Alfredo, Tamaeh Monteiro& Rocha, Paola dos Santos da…[et al.]. Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract of Curatella americana L. Leaves. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114804
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114804
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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