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Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract of Curatella americana L. Leaves
Joint Authors
Rocha, Paola dos Santos da
de Picoli Souza, Kely
Antunes, Kátia Avila
dos Santos, Edson Lucas
Espindola, Priscilla Pereira de Toledo
Pereira, Zefa Valdivina
Lopes, Rafael Henrique Oliveira
Macorini, Luis Fernando Benitez
Alfredo, Tamaeh Monteiro
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
High levels of reactive oxygen species in the body and hyperlipidemia are key factors for the development of cardiovascular diseases such as atherosclerosis.
The present study investigated the antioxidant and hypolipidemic activity of hydroethanolic extract of Curatella americana L.
leaves (ExC).
The antioxidant activity of ExC was assessed by 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) scavenging capacity and protection against hemolysis induced by 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH), followed by quantification of malondialdehyde (MDA).
Wistar rats with hyperlipidemia induced by high-fructose diet (60%) were treated for 60 days with water, simvastatin (30 mg·Kg−1), ciprofibrate (2 mg·Kg−1), and ExC (200 mg·Kg−1).
ExC revealed IC50 of 6.0 ± 0.5 μg·mL−1, an intermediary value among positive controls used in the assay of DPPH scavenging capacity.
At all concentrations (50 to 125 μg·mL−1) and times (60 to 240 min) evaluated, ExC protected erythrocytes against AAPH-induced hemolysis, which was confirmed by lower MDA levels.
In vivo tests showed a reduction of 34 and 45%, respectively, in serum concentration of cholesterol and triglycerides in hyperlipidemic rats treated with ExC, a similar effect compared to the reference drugs, simvastatin and ciprofibrate, respectively.
Together, the results showed the antioxidant activity of ExC and its ability to improve the serum lipid profile in hyperlipidemic rats.
American Psychological Association (APA)
Lopes, Rafael Henrique Oliveira& Macorini, Luis Fernando Benitez& Antunes, Kátia Avila& Espindola, Priscilla Pereira de Toledo& Alfredo, Tamaeh Monteiro& Rocha, Paola dos Santos da…[et al.]. 2016. Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract of Curatella americana L. Leaves. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114804
Modern Language Association (MLA)
Lopes, Rafael Henrique Oliveira…[et al.]. Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract of Curatella americana L. Leaves. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1114804
American Medical Association (AMA)
Lopes, Rafael Henrique Oliveira& Macorini, Luis Fernando Benitez& Antunes, Kátia Avila& Espindola, Priscilla Pereira de Toledo& Alfredo, Tamaeh Monteiro& Rocha, Paola dos Santos da…[et al.]. Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract of Curatella americana L. Leaves. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114804