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Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo
المؤلفون المشاركون
Marędziak, Monika
Kornicka, Katarzyna
Tomaszewski, Krzysztof Andrzej
Henry, Brandon Michael
Wroński, Sebastian
Tarasiuk, Jacek
Marycz, Krzysztof
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-18
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Due to its pleiotropic effects, the commonly used drug metformin has gained renewed interest among medical researchers.
While metformin is mainly used for the treatment of diabetes, recent studies suggest that it may have further application in anticancer and antiaging therapies.
In this study, we investigated the proliferative potential, accumulation of oxidative stress factors, and osteogenic and adipogenic differentiation potential of mouse adipose-derived stem cells (MuASCs) isolated from mice treated with metformin for 8 weeks.
Moreover, we investigated the influence of metformin supplementation on mice bone density and bone element composition.
The ASCs isolated from mice who were treated with metformin for 8 weeks showed highest proliferative potential, generated a robust net of cytoskeletal projections, had reduced expression of markers associated with cellular senescence, and decreased amount of reactive oxygen species in comparison to control group.
Furthermore, we demonstrated that these cells possessed greatest osteogenic differentiation potential, while their adipogenic differentiation ability was reduced.
We also demonstrated that metformin supplementation increases bone density in vivo.
Our result stands as a valuable source of data regarding the in vivo influence of metformin on ASCs and bone density and supports a role for metformin in regenerative medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marycz, Krzysztof& Tomaszewski, Krzysztof Andrzej& Kornicka, Katarzyna& Henry, Brandon Michael& Wroński, Sebastian& Tarasiuk, Jacek…[et al.]. 2016. Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1114838
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marycz, Krzysztof…[et al.]. Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1114838
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marycz, Krzysztof& Tomaszewski, Krzysztof Andrzej& Kornicka, Katarzyna& Henry, Brandon Michael& Wroński, Sebastian& Tarasiuk, Jacek…[et al.]. Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1114838
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114838
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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