Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo
Joint Authors
Marędziak, Monika
Kornicka, Katarzyna
Tomaszewski, Krzysztof Andrzej
Henry, Brandon Michael
Wroński, Sebastian
Tarasiuk, Jacek
Marycz, Krzysztof
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-18
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Due to its pleiotropic effects, the commonly used drug metformin has gained renewed interest among medical researchers.
While metformin is mainly used for the treatment of diabetes, recent studies suggest that it may have further application in anticancer and antiaging therapies.
In this study, we investigated the proliferative potential, accumulation of oxidative stress factors, and osteogenic and adipogenic differentiation potential of mouse adipose-derived stem cells (MuASCs) isolated from mice treated with metformin for 8 weeks.
Moreover, we investigated the influence of metformin supplementation on mice bone density and bone element composition.
The ASCs isolated from mice who were treated with metformin for 8 weeks showed highest proliferative potential, generated a robust net of cytoskeletal projections, had reduced expression of markers associated with cellular senescence, and decreased amount of reactive oxygen species in comparison to control group.
Furthermore, we demonstrated that these cells possessed greatest osteogenic differentiation potential, while their adipogenic differentiation ability was reduced.
We also demonstrated that metformin supplementation increases bone density in vivo.
Our result stands as a valuable source of data regarding the in vivo influence of metformin on ASCs and bone density and supports a role for metformin in regenerative medicine.
American Psychological Association (APA)
Marycz, Krzysztof& Tomaszewski, Krzysztof Andrzej& Kornicka, Katarzyna& Henry, Brandon Michael& Wroński, Sebastian& Tarasiuk, Jacek…[et al.]. 2016. Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1114838
Modern Language Association (MLA)
Marycz, Krzysztof…[et al.]. Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1114838
American Medical Association (AMA)
Marycz, Krzysztof& Tomaszewski, Krzysztof Andrzej& Kornicka, Katarzyna& Henry, Brandon Michael& Wroński, Sebastian& Tarasiuk, Jacek…[et al.]. Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1114838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114838