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Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease
المؤلفون المشاركون
Santos, Renata
Cristóvão, Joana S.
Gomes, Cláudio M.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-10
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD) is the most prevalent age-related dementia affecting millions of people worldwide.
Its main pathological hallmark feature is the formation of insoluble protein deposits of amyloid-β and hyperphosphorylated tau protein into extracellular plaques and intracellular neurofibrillary tangles, respectively.
Many of the mechanistic details of this process remain unknown, but a well-established consequence of protein aggregation is synapse dysfunction and neuronal loss in the AD brain.
Different pathways including mitochondrial dysfunction, oxidative stress, inflammation, and metal metabolism have been suggested to be implicated in this process.
In particular, a body of evidence suggests that neuronal metal ions such as copper, zinc, and iron play important roles in brain function in health and disease states and altered homeostasis and distribution as a common feature across different neurodegenerative diseases and aging.
In this focused review, we overview neuronal proteins that are involved in AD and whose metal binding properties may underlie important biochemical and regulatory processes occurring in the brain during the AD pathophysiological process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cristóvão, Joana S.& Santos, Renata& Gomes, Cláudio M.. 2016. Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114842
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cristóvão, Joana S.…[et al.]. Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114842
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cristóvão, Joana S.& Santos, Renata& Gomes, Cláudio M.. Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114842
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114842
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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