Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease
Joint Authors
Santos, Renata
Cristóvão, Joana S.
Gomes, Cláudio M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the most prevalent age-related dementia affecting millions of people worldwide.
Its main pathological hallmark feature is the formation of insoluble protein deposits of amyloid-β and hyperphosphorylated tau protein into extracellular plaques and intracellular neurofibrillary tangles, respectively.
Many of the mechanistic details of this process remain unknown, but a well-established consequence of protein aggregation is synapse dysfunction and neuronal loss in the AD brain.
Different pathways including mitochondrial dysfunction, oxidative stress, inflammation, and metal metabolism have been suggested to be implicated in this process.
In particular, a body of evidence suggests that neuronal metal ions such as copper, zinc, and iron play important roles in brain function in health and disease states and altered homeostasis and distribution as a common feature across different neurodegenerative diseases and aging.
In this focused review, we overview neuronal proteins that are involved in AD and whose metal binding properties may underlie important biochemical and regulatory processes occurring in the brain during the AD pathophysiological process.
American Psychological Association (APA)
Cristóvão, Joana S.& Santos, Renata& Gomes, Cláudio M.. 2016. Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114842
Modern Language Association (MLA)
Cristóvão, Joana S.…[et al.]. Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114842
American Medical Association (AMA)
Cristóvão, Joana S.& Santos, Renata& Gomes, Cláudio M.. Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114842