Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer
المؤلفون المشاركون
Liao, Duan-Fang
Cao, DeLiang
Wang, Zhiqi
Li, Sai
Cao, Yu
Tian, Xuefei
Zeng, Rong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-28
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Oxidative stress has long been known as a pathogenic factor of ulcerative colitis (UC) and colitis-associated colorectal cancer (CAC), but the effects of secondary carbonyl lesions receive less emphasis.
In inflammatory conditions, reactive oxygen species (ROS), such as superoxide anion free radical ( O 2 ∙ - ), hydrogen peroxide (H2O2), and hydroxyl radical ( H O ∙ ), are produced at high levels and accumulated to cause oxidative stress (OS).
In oxidative status, accumulated ROS can cause protein dysfunction and DNA damage, leading to gene mutations and cell death.
Accumulated ROS could also act as chemical messengers to activate signaling pathways, such as NF-κB and p38 MAPK, to affect cell proliferation, differentiation, and apoptosis.
More importantly, electrophilic carbonyl compounds produced by lipid peroxidation may function as secondary pathogenic factors, causing further protein and membrane lesions.
This may in turn exaggerate oxidative stress, forming a vicious cycle.
Electrophilic carbonyls could also cause DNA mutations and breaks, driving malignant progression of UC.
The secondary lesions caused by carbonyl compounds may be exceptionally important in the case of host carbonyl defensive system deficit, such as aldo-keto reductase 1B10 deficiency.
This review article updates the current understanding of oxidative stress and carbonyl lesions in the development and progression of UC and CAC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Zhiqi& Li, Sai& Cao, Yu& Tian, Xuefei& Zeng, Rong& Liao, Duan-Fang…[et al.]. 2015. Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1114870
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Zhiqi…[et al.]. Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1114870
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Zhiqi& Li, Sai& Cao, Yu& Tian, Xuefei& Zeng, Rong& Liao, Duan-Fang…[et al.]. Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1114870
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114870
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر