Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer
Joint Authors
Liao, Duan-Fang
Cao, DeLiang
Wang, Zhiqi
Li, Sai
Cao, Yu
Tian, Xuefei
Zeng, Rong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Oxidative stress has long been known as a pathogenic factor of ulcerative colitis (UC) and colitis-associated colorectal cancer (CAC), but the effects of secondary carbonyl lesions receive less emphasis.
In inflammatory conditions, reactive oxygen species (ROS), such as superoxide anion free radical ( O 2 ∙ - ), hydrogen peroxide (H2O2), and hydroxyl radical ( H O ∙ ), are produced at high levels and accumulated to cause oxidative stress (OS).
In oxidative status, accumulated ROS can cause protein dysfunction and DNA damage, leading to gene mutations and cell death.
Accumulated ROS could also act as chemical messengers to activate signaling pathways, such as NF-κB and p38 MAPK, to affect cell proliferation, differentiation, and apoptosis.
More importantly, electrophilic carbonyl compounds produced by lipid peroxidation may function as secondary pathogenic factors, causing further protein and membrane lesions.
This may in turn exaggerate oxidative stress, forming a vicious cycle.
Electrophilic carbonyls could also cause DNA mutations and breaks, driving malignant progression of UC.
The secondary lesions caused by carbonyl compounds may be exceptionally important in the case of host carbonyl defensive system deficit, such as aldo-keto reductase 1B10 deficiency.
This review article updates the current understanding of oxidative stress and carbonyl lesions in the development and progression of UC and CAC.
American Psychological Association (APA)
Wang, Zhiqi& Li, Sai& Cao, Yu& Tian, Xuefei& Zeng, Rong& Liao, Duan-Fang…[et al.]. 2015. Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1114870
Modern Language Association (MLA)
Wang, Zhiqi…[et al.]. Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1114870
American Medical Association (AMA)
Wang, Zhiqi& Li, Sai& Cao, Yu& Tian, Xuefei& Zeng, Rong& Liao, Duan-Fang…[et al.]. Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1114870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114870