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Impact of Continuous Erythropoietin Receptor Activator on Selected Biomarkers of Cardiovascular Disease and Left Ventricle Structure and Function in Chronic Kidney Disease
المؤلفون المشاركون
Bartnicki, Piotr
Rysz, Jacek
Franczyk, Beata
Baj, Zbigniew
Majewska, Ewa
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Cardiovascular morbidity and mortality are very high in patients with chronic kidney disease (CKD).
The purpose of this study is to evaluate the impact of continuous erythropoietin receptor activator (CERA) on selected biomarkers of cardiovascular disease, left ventricle structure, and function in CKD.
Material and Methods.
Peripheral blood was collected from 25 CKD patients before and after CERA treatment and 20 healthy subjects.
In serum samples, we assessed inflammatory markers (IL-1β, TNF-RI, TNF-RII, sFas, sFasL, MMP-9, TIMP-1, and TGF-β1), endothelial dysfunction markers (sE-selectin, sICAM-1, and sVCAM-1), and volume-related marker (NT-proBNP).
All subjects underwent echocardiography and were evaluated for selected biochemical parameters (Hb, creatinine, and CRP).
Results.
Evaluated biomarkers and echocardiographic parameters of left ventricle structure were significantly increased but left ventricle EF was significantly decreased in CKD patients compared to controls.
After CERA treatment, we observed a significant increase of Hb and left ventricle EF and a significant decrease of NT-proBNP and MMP-9.
There was a significant negative correlation between Hb and TNF-RI, sICAM-1, and IL-1β.
Conclusions.
Our results indicate that selected biomarkers related to cardiovascular risk are significantly increased in CKD patients compared to controls.
CERA treatment has anti-inflammatory action, diminishes endothelial dysfunction, and improves left ventricle function in these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bartnicki, Piotr& Rysz, Jacek& Franczyk, Beata& Baj, Zbigniew& Majewska, Ewa. 2016. Impact of Continuous Erythropoietin Receptor Activator on Selected Biomarkers of Cardiovascular Disease and Left Ventricle Structure and Function in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114877
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bartnicki, Piotr…[et al.]. Impact of Continuous Erythropoietin Receptor Activator on Selected Biomarkers of Cardiovascular Disease and Left Ventricle Structure and Function in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114877
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bartnicki, Piotr& Rysz, Jacek& Franczyk, Beata& Baj, Zbigniew& Majewska, Ewa. Impact of Continuous Erythropoietin Receptor Activator on Selected Biomarkers of Cardiovascular Disease and Left Ventricle Structure and Function in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114877
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114877
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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