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Impact of Continuous Erythropoietin Receptor Activator on Selected Biomarkers of Cardiovascular Disease and Left Ventricle Structure and Function in Chronic Kidney Disease
Joint Authors
Bartnicki, Piotr
Rysz, Jacek
Franczyk, Beata
Baj, Zbigniew
Majewska, Ewa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Cardiovascular morbidity and mortality are very high in patients with chronic kidney disease (CKD).
The purpose of this study is to evaluate the impact of continuous erythropoietin receptor activator (CERA) on selected biomarkers of cardiovascular disease, left ventricle structure, and function in CKD.
Material and Methods.
Peripheral blood was collected from 25 CKD patients before and after CERA treatment and 20 healthy subjects.
In serum samples, we assessed inflammatory markers (IL-1β, TNF-RI, TNF-RII, sFas, sFasL, MMP-9, TIMP-1, and TGF-β1), endothelial dysfunction markers (sE-selectin, sICAM-1, and sVCAM-1), and volume-related marker (NT-proBNP).
All subjects underwent echocardiography and were evaluated for selected biochemical parameters (Hb, creatinine, and CRP).
Results.
Evaluated biomarkers and echocardiographic parameters of left ventricle structure were significantly increased but left ventricle EF was significantly decreased in CKD patients compared to controls.
After CERA treatment, we observed a significant increase of Hb and left ventricle EF and a significant decrease of NT-proBNP and MMP-9.
There was a significant negative correlation between Hb and TNF-RI, sICAM-1, and IL-1β.
Conclusions.
Our results indicate that selected biomarkers related to cardiovascular risk are significantly increased in CKD patients compared to controls.
CERA treatment has anti-inflammatory action, diminishes endothelial dysfunction, and improves left ventricle function in these patients.
American Psychological Association (APA)
Bartnicki, Piotr& Rysz, Jacek& Franczyk, Beata& Baj, Zbigniew& Majewska, Ewa. 2016. Impact of Continuous Erythropoietin Receptor Activator on Selected Biomarkers of Cardiovascular Disease and Left Ventricle Structure and Function in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114877
Modern Language Association (MLA)
Bartnicki, Piotr…[et al.]. Impact of Continuous Erythropoietin Receptor Activator on Selected Biomarkers of Cardiovascular Disease and Left Ventricle Structure and Function in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114877
American Medical Association (AMA)
Bartnicki, Piotr& Rysz, Jacek& Franczyk, Beata& Baj, Zbigniew& Majewska, Ewa. Impact of Continuous Erythropoietin Receptor Activator on Selected Biomarkers of Cardiovascular Disease and Left Ventricle Structure and Function in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114877