Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics
المؤلفون المشاركون
Yang, Guangdong
Wu, Lingyun
Liu, Mingzhe
Montaut, Sabine
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Hydrogen sulfide (H2S) was originally considered toxic at elevated levels; however just in the past decade H2S has been proposed to be an important gasotransmitter with various physiological and pathophysiological roles in the body.
H2S can be generated endogenously from L-cysteine by multiple enzymes, including cystathionine gamma-lyase, cystathionine beta-synthase, and 3-mercaptopyruvate sulfurtransferase in combination with cysteine aminotransferase.
Prostate cancer is a major health concern and no effective treatment for prostate cancers is available.
H2S has been shown to inhibit cell survival of androgen-independent, androgen-dependent, and antiandrogen-resistant prostate cancer cells through different mechanisms.
Various H2S-releasing compounds, including sulfide salts, diallyl disulfide, diallyl trisulfide, sulforaphane, and other polysulfides, also have been shown to inhibit prostate cancer growth and metastasis.
The expression of H2S-producing enzyme was reduced in both human prostate cancer tissues and prostate cancer cells.
Androgen receptor (AR) signaling is indispensable for the development of castration resistant prostate cancer, and H2S was shown to inhibit AR transactivation and contributes to antiandrogen-resistant status.
In this review, we summarized the current knowledge of H2S signaling in prostate cancer and described the molecular alterations, which may bring this gasotransmitter into the clinic in the near future for developing novel pharmacological and therapeutic interventions for prostate cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Mingzhe& Wu, Lingyun& Montaut, Sabine& Yang, Guangdong. 2016. Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics. Prostate Cancer،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115185
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Mingzhe…[et al.]. Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics. Prostate Cancer No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1115185
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Mingzhe& Wu, Lingyun& Montaut, Sabine& Yang, Guangdong. Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics. Prostate Cancer. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115185
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115185
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر