Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics
Joint Authors
Yang, Guangdong
Wu, Lingyun
Liu, Mingzhe
Montaut, Sabine
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hydrogen sulfide (H2S) was originally considered toxic at elevated levels; however just in the past decade H2S has been proposed to be an important gasotransmitter with various physiological and pathophysiological roles in the body.
H2S can be generated endogenously from L-cysteine by multiple enzymes, including cystathionine gamma-lyase, cystathionine beta-synthase, and 3-mercaptopyruvate sulfurtransferase in combination with cysteine aminotransferase.
Prostate cancer is a major health concern and no effective treatment for prostate cancers is available.
H2S has been shown to inhibit cell survival of androgen-independent, androgen-dependent, and antiandrogen-resistant prostate cancer cells through different mechanisms.
Various H2S-releasing compounds, including sulfide salts, diallyl disulfide, diallyl trisulfide, sulforaphane, and other polysulfides, also have been shown to inhibit prostate cancer growth and metastasis.
The expression of H2S-producing enzyme was reduced in both human prostate cancer tissues and prostate cancer cells.
Androgen receptor (AR) signaling is indispensable for the development of castration resistant prostate cancer, and H2S was shown to inhibit AR transactivation and contributes to antiandrogen-resistant status.
In this review, we summarized the current knowledge of H2S signaling in prostate cancer and described the molecular alterations, which may bring this gasotransmitter into the clinic in the near future for developing novel pharmacological and therapeutic interventions for prostate cancer.
American Psychological Association (APA)
Liu, Mingzhe& Wu, Lingyun& Montaut, Sabine& Yang, Guangdong. 2016. Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics. Prostate Cancer،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115185
Modern Language Association (MLA)
Liu, Mingzhe…[et al.]. Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics. Prostate Cancer No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1115185
American Medical Association (AMA)
Liu, Mingzhe& Wu, Lingyun& Montaut, Sabine& Yang, Guangdong. Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics. Prostate Cancer. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115185
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115185