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Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson’s Disease
المؤلفون المشاركون
Le, Thuong Manh
Hashida, Koji
Ta, Hieu Minh
Takarada-Iemata, Mika
Kokame, Koichi
Kitao, Yasuko
Hori, Osamu
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Herp is an endoplasmic reticulum- (ER-) resident membrane protein that plays a role in ER-associated degradation.
We studied the expression of Herp and its effect on neurodegeneration in a mouse model of Parkinson’s disease (PD), in which both the oxidative stress and the ER stress are evoked.
Eight hours after administering a PD-related neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), to mice, the expression of Herp increased at both the mRNA and the protein levels.
Experiments using Herpud1 +/+ and Herpud1 −/− mice revealed that the status of acute degeneration of nigrostriatal neurons and reactive astrogliosis was comparable between two genotypes after MPTP injection.
However, the expression of a potent antioxidant, heme oxygenase-1 (HO-1), was detected to a higher degree in the astrocytes of Herpud1 −/− mice than in the astrocytes of Herpud1 +/+ mice 24 h after MPTP administration.
Further experiments using cultured astrocytes revealed that the stress response against MPP+, an active form of MPTP, and hydrogen peroxide, both of which cause oxidative stress, was comparable between the two genotypes.
These results suggest that deletion of Herpud1 may cause a slightly higher level of initial damage in the nigrastrial neurons after MPTP administration but is compensated for by higher induction of antioxidants such as HO-1 in astrocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Le, Thuong Manh& Hashida, Koji& Ta, Hieu Minh& Takarada-Iemata, Mika& Kokame, Koichi& Kitao, Yasuko…[et al.]. 2016. Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson’s Disease. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115248
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Le, Thuong Manh…[et al.]. Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson’s Disease. Parkinson’s Disease No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1115248
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Le, Thuong Manh& Hashida, Koji& Ta, Hieu Minh& Takarada-Iemata, Mika& Kokame, Koichi& Kitao, Yasuko…[et al.]. Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson’s Disease. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115248
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115248
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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