Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson’s Disease
المؤلفون المشاركون
Le, Thuong Manh
Hashida, Koji
Ta, Hieu Minh
Takarada-Iemata, Mika
Kokame, Koichi
Kitao, Yasuko
Hori, Osamu
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Herp is an endoplasmic reticulum- (ER-) resident membrane protein that plays a role in ER-associated degradation.
We studied the expression of Herp and its effect on neurodegeneration in a mouse model of Parkinson’s disease (PD), in which both the oxidative stress and the ER stress are evoked.
Eight hours after administering a PD-related neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), to mice, the expression of Herp increased at both the mRNA and the protein levels.
Experiments using Herpud1 +/+ and Herpud1 −/− mice revealed that the status of acute degeneration of nigrostriatal neurons and reactive astrogliosis was comparable between two genotypes after MPTP injection.
However, the expression of a potent antioxidant, heme oxygenase-1 (HO-1), was detected to a higher degree in the astrocytes of Herpud1 −/− mice than in the astrocytes of Herpud1 +/+ mice 24 h after MPTP administration.
Further experiments using cultured astrocytes revealed that the stress response against MPP+, an active form of MPTP, and hydrogen peroxide, both of which cause oxidative stress, was comparable between the two genotypes.
These results suggest that deletion of Herpud1 may cause a slightly higher level of initial damage in the nigrastrial neurons after MPTP administration but is compensated for by higher induction of antioxidants such as HO-1 in astrocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Le, Thuong Manh& Hashida, Koji& Ta, Hieu Minh& Takarada-Iemata, Mika& Kokame, Koichi& Kitao, Yasuko…[et al.]. 2016. Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson’s Disease. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115248
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Le, Thuong Manh…[et al.]. Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson’s Disease. Parkinson’s Disease No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1115248
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Le, Thuong Manh& Hashida, Koji& Ta, Hieu Minh& Takarada-Iemata, Mika& Kokame, Koichi& Kitao, Yasuko…[et al.]. Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson’s Disease. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115248
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115248
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر