Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson’s Disease
Joint Authors
Le, Thuong Manh
Hashida, Koji
Ta, Hieu Minh
Takarada-Iemata, Mika
Kokame, Koichi
Kitao, Yasuko
Hori, Osamu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Herp is an endoplasmic reticulum- (ER-) resident membrane protein that plays a role in ER-associated degradation.
We studied the expression of Herp and its effect on neurodegeneration in a mouse model of Parkinson’s disease (PD), in which both the oxidative stress and the ER stress are evoked.
Eight hours after administering a PD-related neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), to mice, the expression of Herp increased at both the mRNA and the protein levels.
Experiments using Herpud1 +/+ and Herpud1 −/− mice revealed that the status of acute degeneration of nigrostriatal neurons and reactive astrogliosis was comparable between two genotypes after MPTP injection.
However, the expression of a potent antioxidant, heme oxygenase-1 (HO-1), was detected to a higher degree in the astrocytes of Herpud1 −/− mice than in the astrocytes of Herpud1 +/+ mice 24 h after MPTP administration.
Further experiments using cultured astrocytes revealed that the stress response against MPP+, an active form of MPTP, and hydrogen peroxide, both of which cause oxidative stress, was comparable between the two genotypes.
These results suggest that deletion of Herpud1 may cause a slightly higher level of initial damage in the nigrastrial neurons after MPTP administration but is compensated for by higher induction of antioxidants such as HO-1 in astrocytes.
American Psychological Association (APA)
Le, Thuong Manh& Hashida, Koji& Ta, Hieu Minh& Takarada-Iemata, Mika& Kokame, Koichi& Kitao, Yasuko…[et al.]. 2016. Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson’s Disease. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115248
Modern Language Association (MLA)
Le, Thuong Manh…[et al.]. Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson’s Disease. Parkinson’s Disease No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1115248
American Medical Association (AMA)
Le, Thuong Manh& Hashida, Koji& Ta, Hieu Minh& Takarada-Iemata, Mika& Kokame, Koichi& Kitao, Yasuko…[et al.]. Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson’s Disease. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115248