Protease Inhibitors Extracted from Caesalpinia echinata Lam. Affect Kinin Release during Lung Inflammation
المؤلفون المشاركون
Tanaka, Aparecida Sadae
Gozzo, Andrezza Justino
Cruz-Silva, Ilana
Praxedes-Garcia, Priscila
Shimamoto, Kazuaki
Araujo, Mariana Silva
Abreu Nunes, Viviane
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Inflammation is an essential process in many pulmonary diseases in which kinins are generated by protease action on kininogen, a phenomenon that is blocked by protease inhibitors.
We evaluated kinin release in an in vivo lung inflammation model in rats, in the presence or absence of CeKI (C.
echinata kallikrein inhibitor), a plasma kallikrein, cathepsin G, and proteinase-3 inhibitor, and rCeEI (recombinant C.
echinata elastase inhibitor), which inhibits these proteases and also neutrophil elastase.
Wistar rats were intravenously treated with buffer (negative control) or inhibitors and, subsequently, lipopolysaccharide was injected into their lungs.
Blood, bronchoalveolar lavage fluid (BALF), and lung tissue were collected.
In plasma, kinin release was higher in the LPS-treated animals in comparison to CeKI or rCeEI groups.
rCeEI-treated animals presented less kinin than CeKI-treated group.
Our data suggest that kinins play a pivotal role in lung inflammation and may be generated by different enzymes; however, neutrophil elastase seems to be the most important in the lung tissue context.
These results open perspectives for a better understanding of biological process where neutrophil enzymes participate and indicate these plant inhibitors and their recombinant correlates for therapeutic trials involving pulmonary diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cruz-Silva, Ilana& Abreu Nunes, Viviane& Gozzo, Andrezza Justino& Praxedes-Garcia, Priscila& Tanaka, Aparecida Sadae& Shimamoto, Kazuaki…[et al.]. 2016. Protease Inhibitors Extracted from Caesalpinia echinata Lam. Affect Kinin Release during Lung Inflammation. Pulmonary Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115302
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cruz-Silva, Ilana…[et al.]. Protease Inhibitors Extracted from Caesalpinia echinata Lam. Affect Kinin Release during Lung Inflammation. Pulmonary Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1115302
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cruz-Silva, Ilana& Abreu Nunes, Viviane& Gozzo, Andrezza Justino& Praxedes-Garcia, Priscila& Tanaka, Aparecida Sadae& Shimamoto, Kazuaki…[et al.]. Protease Inhibitors Extracted from Caesalpinia echinata Lam. Affect Kinin Release during Lung Inflammation. Pulmonary Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115302
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115302
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر