Protease Inhibitors Extracted from Caesalpinia echinata Lam. Affect Kinin Release during Lung Inflammation
Joint Authors
Tanaka, Aparecida Sadae
Gozzo, Andrezza Justino
Cruz-Silva, Ilana
Praxedes-Garcia, Priscila
Shimamoto, Kazuaki
Araujo, Mariana Silva
Abreu Nunes, Viviane
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inflammation is an essential process in many pulmonary diseases in which kinins are generated by protease action on kininogen, a phenomenon that is blocked by protease inhibitors.
We evaluated kinin release in an in vivo lung inflammation model in rats, in the presence or absence of CeKI (C.
echinata kallikrein inhibitor), a plasma kallikrein, cathepsin G, and proteinase-3 inhibitor, and rCeEI (recombinant C.
echinata elastase inhibitor), which inhibits these proteases and also neutrophil elastase.
Wistar rats were intravenously treated with buffer (negative control) or inhibitors and, subsequently, lipopolysaccharide was injected into their lungs.
Blood, bronchoalveolar lavage fluid (BALF), and lung tissue were collected.
In plasma, kinin release was higher in the LPS-treated animals in comparison to CeKI or rCeEI groups.
rCeEI-treated animals presented less kinin than CeKI-treated group.
Our data suggest that kinins play a pivotal role in lung inflammation and may be generated by different enzymes; however, neutrophil elastase seems to be the most important in the lung tissue context.
These results open perspectives for a better understanding of biological process where neutrophil enzymes participate and indicate these plant inhibitors and their recombinant correlates for therapeutic trials involving pulmonary diseases.
American Psychological Association (APA)
Cruz-Silva, Ilana& Abreu Nunes, Viviane& Gozzo, Andrezza Justino& Praxedes-Garcia, Priscila& Tanaka, Aparecida Sadae& Shimamoto, Kazuaki…[et al.]. 2016. Protease Inhibitors Extracted from Caesalpinia echinata Lam. Affect Kinin Release during Lung Inflammation. Pulmonary Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115302
Modern Language Association (MLA)
Cruz-Silva, Ilana…[et al.]. Protease Inhibitors Extracted from Caesalpinia echinata Lam. Affect Kinin Release during Lung Inflammation. Pulmonary Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1115302
American Medical Association (AMA)
Cruz-Silva, Ilana& Abreu Nunes, Viviane& Gozzo, Andrezza Justino& Praxedes-Garcia, Priscila& Tanaka, Aparecida Sadae& Shimamoto, Kazuaki…[et al.]. Protease Inhibitors Extracted from Caesalpinia echinata Lam. Affect Kinin Release during Lung Inflammation. Pulmonary Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115302