How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review
المؤلفون المشاركون
Ali, Samina
Drendel, Amy L.
Hartling, Lisa
Dryden, Donna M.
Chordiya, Pritam
Johnson, David W.
Plint, Amy C.
Stang, Antonia
McGrath, Patrick J.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-18
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Background.
Fear of adverse events and occurrence of side effects are commonly cited by families and physicians as obstructive to appropriate use of pain medication in children.
We examined evidence comparing the safety profiles of three groups of oral medications, acetaminophen, nonsteroidal anti-inflammatory drugs, and opioids, to manage acute nonsurgical pain in children (<18 years) treated in ambulatory settings.
Methods.
A comprehensive search was performed to July 2015, including review of national data registries.
Two reviewers screened articles for inclusion, assessed methodological quality, and extracted data.
Risks (incidence rates) were pooled using a random effects model.
Results.
Forty-four studies were included; 23 reported on adverse events.
Based on limited current evidence, acetaminophen, ibuprofen, and opioids have similar nausea and vomiting profiles.
Opioids have the greatest risk of central nervous system adverse events.
Dual therapy with a nonopioid/opioid combination resulted in a lower risk of adverse events than opioids alone.
Conclusions.
Ibuprofen and acetaminophen have similar reported adverse effects and notably less adverse events than opioids.
Dual therapy with a nonopioid/opioid combination confers a protective effect for adverse events over opioids alone.
This research highlights challenges in assessing medication safety, including lack of more detailed information in registry data, and inconsistent reporting in trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hartling, Lisa& Ali, Samina& Dryden, Donna M.& Chordiya, Pritam& Johnson, David W.& Plint, Amy C.…[et al.]. 2016. How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review. Pain Research and Management،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1115458
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hartling, Lisa…[et al.]. How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review. Pain Research and Management No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1115458
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hartling, Lisa& Ali, Samina& Dryden, Donna M.& Chordiya, Pritam& Johnson, David W.& Plint, Amy C.…[et al.]. How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review. Pain Research and Management. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1115458
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115458
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر