How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review
Joint Authors
Ali, Samina
Drendel, Amy L.
Hartling, Lisa
Dryden, Donna M.
Chordiya, Pritam
Johnson, David W.
Plint, Amy C.
Stang, Antonia
McGrath, Patrick J.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-18
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
Fear of adverse events and occurrence of side effects are commonly cited by families and physicians as obstructive to appropriate use of pain medication in children.
We examined evidence comparing the safety profiles of three groups of oral medications, acetaminophen, nonsteroidal anti-inflammatory drugs, and opioids, to manage acute nonsurgical pain in children (<18 years) treated in ambulatory settings.
Methods.
A comprehensive search was performed to July 2015, including review of national data registries.
Two reviewers screened articles for inclusion, assessed methodological quality, and extracted data.
Risks (incidence rates) were pooled using a random effects model.
Results.
Forty-four studies were included; 23 reported on adverse events.
Based on limited current evidence, acetaminophen, ibuprofen, and opioids have similar nausea and vomiting profiles.
Opioids have the greatest risk of central nervous system adverse events.
Dual therapy with a nonopioid/opioid combination resulted in a lower risk of adverse events than opioids alone.
Conclusions.
Ibuprofen and acetaminophen have similar reported adverse effects and notably less adverse events than opioids.
Dual therapy with a nonopioid/opioid combination confers a protective effect for adverse events over opioids alone.
This research highlights challenges in assessing medication safety, including lack of more detailed information in registry data, and inconsistent reporting in trials.
American Psychological Association (APA)
Hartling, Lisa& Ali, Samina& Dryden, Donna M.& Chordiya, Pritam& Johnson, David W.& Plint, Amy C.…[et al.]. 2016. How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review. Pain Research and Management،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1115458
Modern Language Association (MLA)
Hartling, Lisa…[et al.]. How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review. Pain Research and Management No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1115458
American Medical Association (AMA)
Hartling, Lisa& Ali, Samina& Dryden, Donna M.& Chordiya, Pritam& Johnson, David W.& Plint, Amy C.…[et al.]. How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review. Pain Research and Management. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1115458
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115458