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Confirmed Activity and Tolerability of Weekly Paclitaxel in the Treatment of Advanced Angiosarcoma
المؤلفون المشاركون
Di Maio, Massimo
Perrone, Francesco
Pizzolorusso, Antonio
Grignani, Giovanni
Gebbia, Vittorio
Buonadonna, Angela
De Chiara, Annarosaria
Fazioli, Flavio
De Palma, Giampaolo
Galizia, Danilo
Arcara, Carlo
Mozzillo, Nicola
Apice, Gaetano
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
In several prospective and retrospective studies, weekly paclitaxel showed promising activity in patients with angiosarcoma.
Patients and Methods.
Our study was originally designed as a prospective, phase II multicenter trial for patients younger than 75, with ECOG performance status 0–2, affected by locally advanced or metastatic angiosarcoma.
Patients received paclitaxel 80 mg/m2 intravenously, at days 1, 8, and 15 every 4 weeks, until disease progression or unacceptable toxicity.
Primary endpoint was objective response.
Results.
Eight patients were enrolled but, due to very slow accrual, the trial was prematurely stopped and further 10 patients were retrospectively included in the analysis.
Out of 17 evaluable patients, 6 patients obtained an objective response (5 partial, 1 complete), with an objective response rate of 35% (95% confidence interval 17%–59%).
Of note, five responses were obtained in pretreated patients.
In the paper, details of overall survival, progression-free survival, and tolerability are reported.
Conclusions.
In this small series of patients with locally advanced or metastatic angiosarcoma, weekly paclitaxel was confirmed to be well tolerated and active even in pretreated patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Apice, Gaetano& Pizzolorusso, Antonio& Di Maio, Massimo& Grignani, Giovanni& Gebbia, Vittorio& Buonadonna, Angela…[et al.]. 2016. Confirmed Activity and Tolerability of Weekly Paclitaxel in the Treatment of Advanced Angiosarcoma. Complexity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115779
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Apice, Gaetano…[et al.]. Confirmed Activity and Tolerability of Weekly Paclitaxel in the Treatment of Advanced Angiosarcoma. Complexity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1115779
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Apice, Gaetano& Pizzolorusso, Antonio& Di Maio, Massimo& Grignani, Giovanni& Gebbia, Vittorio& Buonadonna, Angela…[et al.]. Confirmed Activity and Tolerability of Weekly Paclitaxel in the Treatment of Advanced Angiosarcoma. Complexity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115779
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115779
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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