Confirmed Activity and Tolerability of Weekly Paclitaxel in the Treatment of Advanced Angiosarcoma
Joint Authors
Di Maio, Massimo
Perrone, Francesco
Pizzolorusso, Antonio
Grignani, Giovanni
Gebbia, Vittorio
Buonadonna, Angela
De Chiara, Annarosaria
Fazioli, Flavio
De Palma, Giampaolo
Galizia, Danilo
Arcara, Carlo
Mozzillo, Nicola
Apice, Gaetano
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
In several prospective and retrospective studies, weekly paclitaxel showed promising activity in patients with angiosarcoma.
Patients and Methods.
Our study was originally designed as a prospective, phase II multicenter trial for patients younger than 75, with ECOG performance status 0–2, affected by locally advanced or metastatic angiosarcoma.
Patients received paclitaxel 80 mg/m2 intravenously, at days 1, 8, and 15 every 4 weeks, until disease progression or unacceptable toxicity.
Primary endpoint was objective response.
Results.
Eight patients were enrolled but, due to very slow accrual, the trial was prematurely stopped and further 10 patients were retrospectively included in the analysis.
Out of 17 evaluable patients, 6 patients obtained an objective response (5 partial, 1 complete), with an objective response rate of 35% (95% confidence interval 17%–59%).
Of note, five responses were obtained in pretreated patients.
In the paper, details of overall survival, progression-free survival, and tolerability are reported.
Conclusions.
In this small series of patients with locally advanced or metastatic angiosarcoma, weekly paclitaxel was confirmed to be well tolerated and active even in pretreated patients.
American Psychological Association (APA)
Apice, Gaetano& Pizzolorusso, Antonio& Di Maio, Massimo& Grignani, Giovanni& Gebbia, Vittorio& Buonadonna, Angela…[et al.]. 2016. Confirmed Activity and Tolerability of Weekly Paclitaxel in the Treatment of Advanced Angiosarcoma. Complexity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115779
Modern Language Association (MLA)
Apice, Gaetano…[et al.]. Confirmed Activity and Tolerability of Weekly Paclitaxel in the Treatment of Advanced Angiosarcoma. Complexity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1115779
American Medical Association (AMA)
Apice, Gaetano& Pizzolorusso, Antonio& Di Maio, Massimo& Grignani, Giovanni& Gebbia, Vittorio& Buonadonna, Angela…[et al.]. Confirmed Activity and Tolerability of Weekly Paclitaxel in the Treatment of Advanced Angiosarcoma. Complexity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115779