GDNF Enhances Therapeutic Efficiency of Neural Stem Cells-Based Therapy in Chronic Experimental Allergic Encephalomyelitis in Rat
المؤلفون المشاركون
Gao, Xiaoqing
Yang, Chaoxian
Du, Jie
Deng, Li
Wang, Yun
Yin, Ling
Yuan, Qionglan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-26
دولة النشر
مصر
عدد الصفحات
9
الملخص EN
Multiple sclerosis (MS) is an autoimmune disease in the CNS.
The current immunomodulating drugs for MS do not effectively prevent the progressive neurological decline.
Neural stem cells (NSCs) transplantation has been proven to promote repair and functional recovery of experimental allergic encephalomyelitis (EAE) animal model for MS, and glial cell line-derived neurotrophic factor (GDNF) has also been found to have capability of promoting axonal regeneration and remyelination of regenerating axons.
In the present study, to assess whether GDNF would enhance therapeutic effect of NSCs for EAE, GDNF gene-modified NSCs (GDNF/NSCs) and native NSCs were transplanted into each lateral ventricle of rats at 10 days and rats were sacrificed at 60 days after EAE immunization.
We found that NSCs significantly reduced the clinical signs, and GDNF gene-modification further promoted functional recovery.
GDNF/NSCs more profoundly suppressed brain inflammation and improved density of myelin compared with NSCs.
The survival of GDNF/NSCs was significantly higher than that of transplanted NSCs.
Transplanted GDNF/NSCs, in contrast to NSCs, differentiated into more neurons and oligodendrocytes.
Moreover, the mRNA expression of oligodendrocyte lineage cells in rats with GDNF/NSCs was significantly increased compared to rats with NSCs.
These results suggest that GDNF enhances therapeutic efficiency of NSCs-based therapy for EAE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Xiaoqing& Deng, Li& Wang, Yun& Yin, Ling& Yang, Chaoxian& Du, Jie…[et al.]. 2016. GDNF Enhances Therapeutic Efficiency of Neural Stem Cells-Based Therapy in Chronic Experimental Allergic Encephalomyelitis in Rat. Stem Cells International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1116043
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Xiaoqing…[et al.]. GDNF Enhances Therapeutic Efficiency of Neural Stem Cells-Based Therapy in Chronic Experimental Allergic Encephalomyelitis in Rat. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1116043
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Xiaoqing& Deng, Li& Wang, Yun& Yin, Ling& Yang, Chaoxian& Du, Jie…[et al.]. GDNF Enhances Therapeutic Efficiency of Neural Stem Cells-Based Therapy in Chronic Experimental Allergic Encephalomyelitis in Rat. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1116043
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116043
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر